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A Dynamical Model of Genetic Networks for Cell Differentiation
A mathematical model is proposed which is able to describe the most important features of cell differentiation, without requiring specific detailed assumptions concerning the interactions which drive the phenomenon. On the contrary, cell differentiation is described here as an emergent property of a...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
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Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060813/ https://www.ncbi.nlm.nih.gov/pubmed/21464974 http://dx.doi.org/10.1371/journal.pone.0017703 |
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author | Villani, Marco Barbieri, Alessia Serra, Roberto |
author_facet | Villani, Marco Barbieri, Alessia Serra, Roberto |
author_sort | Villani, Marco |
collection | PubMed |
description | A mathematical model is proposed which is able to describe the most important features of cell differentiation, without requiring specific detailed assumptions concerning the interactions which drive the phenomenon. On the contrary, cell differentiation is described here as an emergent property of a generic model of the underlying gene regulatory network, and it can therefore be applied to a variety of different organisms. The model points to a peculiar role of cellular noise in differentiation and leads to non trivial predictions which could be subject to experimental testing. Moreover, a single model proves able to describe several different phenomena observed in various differentiation processes. |
format | Text |
id | pubmed-3060813 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-30608132011-04-04 A Dynamical Model of Genetic Networks for Cell Differentiation Villani, Marco Barbieri, Alessia Serra, Roberto PLoS One Research Article A mathematical model is proposed which is able to describe the most important features of cell differentiation, without requiring specific detailed assumptions concerning the interactions which drive the phenomenon. On the contrary, cell differentiation is described here as an emergent property of a generic model of the underlying gene regulatory network, and it can therefore be applied to a variety of different organisms. The model points to a peculiar role of cellular noise in differentiation and leads to non trivial predictions which could be subject to experimental testing. Moreover, a single model proves able to describe several different phenomena observed in various differentiation processes. Public Library of Science 2011-03-18 /pmc/articles/PMC3060813/ /pubmed/21464974 http://dx.doi.org/10.1371/journal.pone.0017703 Text en Serra et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Villani, Marco Barbieri, Alessia Serra, Roberto A Dynamical Model of Genetic Networks for Cell Differentiation |
title | A Dynamical Model of Genetic Networks for Cell Differentiation |
title_full | A Dynamical Model of Genetic Networks for Cell Differentiation |
title_fullStr | A Dynamical Model of Genetic Networks for Cell Differentiation |
title_full_unstemmed | A Dynamical Model of Genetic Networks for Cell Differentiation |
title_short | A Dynamical Model of Genetic Networks for Cell Differentiation |
title_sort | dynamical model of genetic networks for cell differentiation |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060813/ https://www.ncbi.nlm.nih.gov/pubmed/21464974 http://dx.doi.org/10.1371/journal.pone.0017703 |
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