Nerve Agent Hydrolysis Activity Designed into a Human Drug Metabolism Enzyme

Organophosphorus (OP) nerve agents are potent suicide inhibitors of the essential neurotransmitter-regulating enzyme acetylcholinesterase. Due to their acute toxicity, there is significant interest in developing effective countermeasures to OP poisoning. Here we impart nerve agent hydrolysis activit...

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Detalles Bibliográficos
Autores principales: Hemmert, Andrew C., Otto, Tamara C., Chica, Roberto A., Wierdl, Monika, Edwards, Jonathan S., Lewis, Steven L., Edwards, Carol C., Tsurkan, Lyudmila, Cadieux, C. Linn, Kasten, Shane A., Cashman, John R., Mayo, Stephen L., Potter, Philip M., Cerasoli, Douglas M., Redinbo, Matthew R.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060870/
https://www.ncbi.nlm.nih.gov/pubmed/21445272
http://dx.doi.org/10.1371/journal.pone.0017441

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