The p53 Inhibitor MDM2 Facilitates Sonic Hedgehog-Mediated Tumorigenesis and Influences Cerebellar Foliation

Disruption of cerebellar granular neuronal precursor (GNP) maturation can result in defects in motor coordination and learning, or in medulloblastoma, the most common childhood brain tumor. The Sonic Hedgehog (Shh) pathway is important for GNP proliferation; however, the factors regulating the exten...

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Detalles Bibliográficos
Autores principales: Malek, Reem, Matta, Jennifer, Taylor, Natalie, Perry, Mary Ellen, Mendrysa, Susan M.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060880/
https://www.ncbi.nlm.nih.gov/pubmed/21437245
http://dx.doi.org/10.1371/journal.pone.0017884

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060880/
https://www.ncbi.nlm.nih.gov/pubmed/21437245
http://dx.doi.org/10.1371/journal.pone.0017884

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