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Seroprevalence of Pandemic (H1N1) 2009 in Pregnant Women in China: An Observational Study

BACKGROUND: We investigated the seropositive rates and persistence of antibody against pandemic (H1N1) 2009 virus (pH1N1) in pregnant women and voluntary blood donors after the second wave of the pandemic in Nanjing, China. METHODOLOGY/PRINCIPAL FINDINGS: Serum samples of unvaccinated pregnant women...

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Autores principales: Huo, Xiang, Qi, Xian, Tang, Fenyang, Zu, Rongqiang, Li, Liang, Wu, Bin, Qin, Yuanfang, Ji, Hong, Fu, Jianguang, Wang, Shenjiao, Tian, Hua, Hu, Zhibin, Yang, Haitao, Zhou, Minghao, Wang, Hua, Zhu, Fengcai
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060915/
https://www.ncbi.nlm.nih.gov/pubmed/21437256
http://dx.doi.org/10.1371/journal.pone.0017995
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author Huo, Xiang
Qi, Xian
Tang, Fenyang
Zu, Rongqiang
Li, Liang
Wu, Bin
Qin, Yuanfang
Ji, Hong
Fu, Jianguang
Wang, Shenjiao
Tian, Hua
Hu, Zhibin
Yang, Haitao
Zhou, Minghao
Wang, Hua
Zhu, Fengcai
author_facet Huo, Xiang
Qi, Xian
Tang, Fenyang
Zu, Rongqiang
Li, Liang
Wu, Bin
Qin, Yuanfang
Ji, Hong
Fu, Jianguang
Wang, Shenjiao
Tian, Hua
Hu, Zhibin
Yang, Haitao
Zhou, Minghao
Wang, Hua
Zhu, Fengcai
author_sort Huo, Xiang
collection PubMed
description BACKGROUND: We investigated the seropositive rates and persistence of antibody against pandemic (H1N1) 2009 virus (pH1N1) in pregnant women and voluntary blood donors after the second wave of the pandemic in Nanjing, China. METHODOLOGY/PRINCIPAL FINDINGS: Serum samples of unvaccinated pregnant women (n = 720) and voluntary blood donors (n = 320) were collected after the second wave of 2009 pandemic in Nanjing. All samples were tested against pH1N1 strain (A/California/7/2009) with hemagglutination inhibition assay. A significant decline in seropositive rates, from above 50% to about 20%, was observed in pregnant women and voluntary blood donors fifteen weeks after the second wave of the pandemic. A quarter of the samples were tested against a seasonal H1N1 strain (A/Brisbane/59/2007). The antibody titers against pH1N1 strain were found to correlate positively with those against seasonal H1N1 strain. The correlation was modest but statistically significant. CONCLUSIONS AND SIGNIFICANCE: The high seropositive rates in both pregnant women and voluntary blood donors suggested that the pH1N1 virus had widely spread in these two populations. Immunity derived from natural infection seemed not to be persistent well.
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spelling pubmed-30609152011-03-23 Seroprevalence of Pandemic (H1N1) 2009 in Pregnant Women in China: An Observational Study Huo, Xiang Qi, Xian Tang, Fenyang Zu, Rongqiang Li, Liang Wu, Bin Qin, Yuanfang Ji, Hong Fu, Jianguang Wang, Shenjiao Tian, Hua Hu, Zhibin Yang, Haitao Zhou, Minghao Wang, Hua Zhu, Fengcai PLoS One Research Article BACKGROUND: We investigated the seropositive rates and persistence of antibody against pandemic (H1N1) 2009 virus (pH1N1) in pregnant women and voluntary blood donors after the second wave of the pandemic in Nanjing, China. METHODOLOGY/PRINCIPAL FINDINGS: Serum samples of unvaccinated pregnant women (n = 720) and voluntary blood donors (n = 320) were collected after the second wave of 2009 pandemic in Nanjing. All samples were tested against pH1N1 strain (A/California/7/2009) with hemagglutination inhibition assay. A significant decline in seropositive rates, from above 50% to about 20%, was observed in pregnant women and voluntary blood donors fifteen weeks after the second wave of the pandemic. A quarter of the samples were tested against a seasonal H1N1 strain (A/Brisbane/59/2007). The antibody titers against pH1N1 strain were found to correlate positively with those against seasonal H1N1 strain. The correlation was modest but statistically significant. CONCLUSIONS AND SIGNIFICANCE: The high seropositive rates in both pregnant women and voluntary blood donors suggested that the pH1N1 virus had widely spread in these two populations. Immunity derived from natural infection seemed not to be persistent well. Public Library of Science 2011-03-18 /pmc/articles/PMC3060915/ /pubmed/21437256 http://dx.doi.org/10.1371/journal.pone.0017995 Text en Huo et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Huo, Xiang
Qi, Xian
Tang, Fenyang
Zu, Rongqiang
Li, Liang
Wu, Bin
Qin, Yuanfang
Ji, Hong
Fu, Jianguang
Wang, Shenjiao
Tian, Hua
Hu, Zhibin
Yang, Haitao
Zhou, Minghao
Wang, Hua
Zhu, Fengcai
Seroprevalence of Pandemic (H1N1) 2009 in Pregnant Women in China: An Observational Study
title Seroprevalence of Pandemic (H1N1) 2009 in Pregnant Women in China: An Observational Study
title_full Seroprevalence of Pandemic (H1N1) 2009 in Pregnant Women in China: An Observational Study
title_fullStr Seroprevalence of Pandemic (H1N1) 2009 in Pregnant Women in China: An Observational Study
title_full_unstemmed Seroprevalence of Pandemic (H1N1) 2009 in Pregnant Women in China: An Observational Study
title_short Seroprevalence of Pandemic (H1N1) 2009 in Pregnant Women in China: An Observational Study
title_sort seroprevalence of pandemic (h1n1) 2009 in pregnant women in china: an observational study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060915/
https://www.ncbi.nlm.nih.gov/pubmed/21437256
http://dx.doi.org/10.1371/journal.pone.0017995
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