Sequence-dependent cooperative binding of p53 to DNA targets and its relationship to the structural properties of the DNA targets

The prime mechanism by which p53 acts as a tumor suppressor is as a transcription factor regulating the expression of diverse downstream genes. The DNA-binding domain of p53 (p53DBD) interacts with defined DNA sites and is the main target for mutations in human primary tumors. Here, we show that the...

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Detalles Bibliográficos
Autores principales: Beno, Itai, Rosenthal, Karin, Levitine, Michael, Shaulov, Lihi, Haran, Tali E.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061056/
https://www.ncbi.nlm.nih.gov/pubmed/21071400
http://dx.doi.org/10.1093/nar/gkq1044

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061056/
https://www.ncbi.nlm.nih.gov/pubmed/21071400
http://dx.doi.org/10.1093/nar/gkq1044

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