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Sequence-dependent cooperative binding of p53 to DNA targets and its relationship to the structural properties of the DNA targets
The prime mechanism by which p53 acts as a tumor suppressor is as a transcription factor regulating the expression of diverse downstream genes. The DNA-binding domain of p53 (p53DBD) interacts with defined DNA sites and is the main target for mutations in human primary tumors. Here, we show that the...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061056/ https://www.ncbi.nlm.nih.gov/pubmed/21071400 http://dx.doi.org/10.1093/nar/gkq1044 |