RTEL1: an essential helicase for telomere maintenance and the regulation of homologous recombination

Telomere maintenance and DNA repair are crucial processes that protect the genome against instability. RTEL1, an essential iron–sulfur cluster-containing helicase, is a dominant factor that controls telomere length in mice and is required for telomere integrity. In addition, RTEL1 promotes synthesis...

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Autores principales: Uringa, Evert-Jan, Youds, Jillian L., Lisaingo, Kathleen, Lansdorp, Peter M., Boulton, Simon J.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Survey and Summary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061057/
https://www.ncbi.nlm.nih.gov/pubmed/21097466
http://dx.doi.org/10.1093/nar/gkq1045
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author Uringa, Evert-Jan
Youds, Jillian L.
Lisaingo, Kathleen
Lansdorp, Peter M.
Boulton, Simon J.
author_facet Uringa, Evert-Jan
Youds, Jillian L.
Lisaingo, Kathleen
Lansdorp, Peter M.
Boulton, Simon J.
author_sort Uringa, Evert-Jan
collection PubMed
description Telomere maintenance and DNA repair are crucial processes that protect the genome against instability. RTEL1, an essential iron–sulfur cluster-containing helicase, is a dominant factor that controls telomere length in mice and is required for telomere integrity. In addition, RTEL1 promotes synthesis-dependent strand annealing to direct DNA double-strand breaks into non-crossover outcomes during mitotic repair and in meiosis. Here, we review the role of RTEL1 in telomere maintenance and homologous recombination and discuss models linking RTEL1’s enzymatic activity to its function in telomere maintenance and DNA repair.
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spelling pubmed-30610572011-03-21 RTEL1: an essential helicase for telomere maintenance and the regulation of homologous recombination Uringa, Evert-Jan Youds, Jillian L. Lisaingo, Kathleen Lansdorp, Peter M. Boulton, Simon J. Nucleic Acids Res Survey and Summary Telomere maintenance and DNA repair are crucial processes that protect the genome against instability. RTEL1, an essential iron–sulfur cluster-containing helicase, is a dominant factor that controls telomere length in mice and is required for telomere integrity. In addition, RTEL1 promotes synthesis-dependent strand annealing to direct DNA double-strand breaks into non-crossover outcomes during mitotic repair and in meiosis. Here, we review the role of RTEL1 in telomere maintenance and homologous recombination and discuss models linking RTEL1’s enzymatic activity to its function in telomere maintenance and DNA repair. Oxford University Press 2011-03 2010-11-18 /pmc/articles/PMC3061057/ /pubmed/21097466 http://dx.doi.org/10.1093/nar/gkq1045 Text en © The Author(s) 2010. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/2.5 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Survey and Summary
Uringa, Evert-Jan
Youds, Jillian L.
Lisaingo, Kathleen
Lansdorp, Peter M.
Boulton, Simon J.
RTEL1: an essential helicase for telomere maintenance and the regulation of homologous recombination
title RTEL1: an essential helicase for telomere maintenance and the regulation of homologous recombination
title_full RTEL1: an essential helicase for telomere maintenance and the regulation of homologous recombination
title_fullStr RTEL1: an essential helicase for telomere maintenance and the regulation of homologous recombination
title_full_unstemmed RTEL1: an essential helicase for telomere maintenance and the regulation of homologous recombination
title_short RTEL1: an essential helicase for telomere maintenance and the regulation of homologous recombination
title_sort rtel1: an essential helicase for telomere maintenance and the regulation of homologous recombination
topic Survey and Summary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061057/
https://www.ncbi.nlm.nih.gov/pubmed/21097466
http://dx.doi.org/10.1093/nar/gkq1045
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