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5′-end surveillance by Xrn2 acts as a shared mechanism for mammalian pre-rRNA maturation and decay
Ribosome biogenesis requires multiple nuclease activities to process pre-rRNA transcripts into mature rRNA species and eliminate defective products of transcription and processing. We find that in mammalian cells, the 5′ exonuclease Xrn2 plays a major role in both maturation of rRNA and degradation...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061060/ https://www.ncbi.nlm.nih.gov/pubmed/21036871 http://dx.doi.org/10.1093/nar/gkq1050 |