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Direct involvement of the TEN domain at the active site of human telomerase

Telomerase is a ribonucleoprotein that adds DNA to the ends of chromosomes. The catalytic protein subunit of telomerase (TERT) contains an N-terminal domain (TEN) that is important for activity and processivity. Here we describe a mutation in the TEN domain of human TERT that results in a greatly in...

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Detalles Bibliográficos
Autores principales:	Jurczyluk, Julie, Nouwens, Amanda S., Holien, Jessica K., Adams, Timothy E., Lovrecz, George O., Parker, Michael W., Cohen, Scott B., Bryan, Tracy M.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2011
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061064/ https://www.ncbi.nlm.nih.gov/pubmed/21051362 http://dx.doi.org/10.1093/nar/gkq1083

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