Synthesis and structural characterization of piperazino-modified DNA that favours hybridization towards DNA over RNA

We report the synthesis of two C4′-modified DNA analogues and characterize their structural impact on dsDNA duplexes. The 4′-C-piperazinomethyl modification stabilizes dsDNA by up to 5°C per incorporation. Extension of the modification with a butanoyl-linked pyrene increases the dsDNA stabilization...

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Detalles Bibliográficos
Autores principales: Skov, Joan, Bryld, Torsten, Lindegaard, Dorthe, Nielsen, Katrine E., Højland, Torben, Wengel, Jesper, Petersen, Michael
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Synthetic Biology and Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061067/
https://www.ncbi.nlm.nih.gov/pubmed/21062815
http://dx.doi.org/10.1093/nar/gkq1123

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