Improved specificity of gene silencing by siRNAs containing unlocked nucleobase analogs

siRNAs confer sequence specific and robust silencing of mRNA. By virtue of these properties, siRNAs have become therapeutic candidates for disease intervention. However, their use as therapeutic agents can be hampered by unintended off-target effects by either or both strands of the siRNA duplex. We...

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Detalles Bibliográficos
Autores principales: Vaish, Narendra, Chen, Feng, Seth, Shaguna, Fosnaugh, Kathy, Liu, Yan, Adami, Roger, Brown, Tod, Chen, Yan, Harvie, Pierrot, Johns, Rachel, Severson, Gregory, Granger, Brian, Charmley, Patrick, Houston, Michael, Templin, Michael V., Polisky, Barry
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061082/
https://www.ncbi.nlm.nih.gov/pubmed/21047800
http://dx.doi.org/10.1093/nar/gkq961

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