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Defective Osteogenic Differentiation in the Development of Osteosarcoma

Osteosarcoma (OS) is associated with poor prognosis due to its high incidence of metastasis and chemoresistance. It often arises in areas of rapid bone growth in long bones during the adolescent growth spurt. Although certain genetic conditions and alterations increase the risk of developing OS, the...

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Autores principales: Wagner, Eric R., Luther, Gaurav, Zhu, Gaohui, Luo, Qing, Shi, Qiong, Kim, Stephanie H., Gao, Jian-Li, Huang, Enyi, Gao, Yanhong, Yang, Ke, Wang, Linyuan, Teven, Chad, Luo, Xiaoji, Liu, Xing, Li, Mi, Hu, Ning, Su, Yuxi, Bi, Yang, He, Bai-Cheng, Tang, Ni, Luo, Jinyong, Chen, Liang, Zuo, Guowei, Rames, Richard, Haydon, Rex C., Luu, Hue H., He, Tong-Chuan
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061279/
https://www.ncbi.nlm.nih.gov/pubmed/21437219
http://dx.doi.org/10.1155/2011/325238
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author Wagner, Eric R.
Luther, Gaurav
Zhu, Gaohui
Luo, Qing
Shi, Qiong
Kim, Stephanie H.
Gao, Jian-Li
Huang, Enyi
Gao, Yanhong
Yang, Ke
Wang, Linyuan
Teven, Chad
Luo, Xiaoji
Liu, Xing
Li, Mi
Hu, Ning
Su, Yuxi
Bi, Yang
He, Bai-Cheng
Tang, Ni
Luo, Jinyong
Chen, Liang
Zuo, Guowei
Rames, Richard
Haydon, Rex C.
Luu, Hue H.
He, Tong-Chuan
author_facet Wagner, Eric R.
Luther, Gaurav
Zhu, Gaohui
Luo, Qing
Shi, Qiong
Kim, Stephanie H.
Gao, Jian-Li
Huang, Enyi
Gao, Yanhong
Yang, Ke
Wang, Linyuan
Teven, Chad
Luo, Xiaoji
Liu, Xing
Li, Mi
Hu, Ning
Su, Yuxi
Bi, Yang
He, Bai-Cheng
Tang, Ni
Luo, Jinyong
Chen, Liang
Zuo, Guowei
Rames, Richard
Haydon, Rex C.
Luu, Hue H.
He, Tong-Chuan
author_sort Wagner, Eric R.
collection PubMed
description Osteosarcoma (OS) is associated with poor prognosis due to its high incidence of metastasis and chemoresistance. It often arises in areas of rapid bone growth in long bones during the adolescent growth spurt. Although certain genetic conditions and alterations increase the risk of developing OS, the molecular pathogenesis is poorly understood. Recently, defects in differentiation have been linked to cancers, as they are associated with high cell proliferation. Treatments overcoming these defects enable terminal differentiation and subsequent tumor inhibition. OS development may be associated with defects in osteogenic differentiation. While early regulators of osteogenesis are unable to bypass these defects, late osteogenic regulators, including Runx2 and Osterix, are able to overcome some of the defects and inhibit tumor propagation through promoting osteogenic differentiation. Further understanding of the relationship between defects in osteogenic differentiation and tumor development holds tremendous potential in treating OS.
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spelling pubmed-30612792011-03-24 Defective Osteogenic Differentiation in the Development of Osteosarcoma Wagner, Eric R. Luther, Gaurav Zhu, Gaohui Luo, Qing Shi, Qiong Kim, Stephanie H. Gao, Jian-Li Huang, Enyi Gao, Yanhong Yang, Ke Wang, Linyuan Teven, Chad Luo, Xiaoji Liu, Xing Li, Mi Hu, Ning Su, Yuxi Bi, Yang He, Bai-Cheng Tang, Ni Luo, Jinyong Chen, Liang Zuo, Guowei Rames, Richard Haydon, Rex C. Luu, Hue H. He, Tong-Chuan Sarcoma Review Article Osteosarcoma (OS) is associated with poor prognosis due to its high incidence of metastasis and chemoresistance. It often arises in areas of rapid bone growth in long bones during the adolescent growth spurt. Although certain genetic conditions and alterations increase the risk of developing OS, the molecular pathogenesis is poorly understood. Recently, defects in differentiation have been linked to cancers, as they are associated with high cell proliferation. Treatments overcoming these defects enable terminal differentiation and subsequent tumor inhibition. OS development may be associated with defects in osteogenic differentiation. While early regulators of osteogenesis are unable to bypass these defects, late osteogenic regulators, including Runx2 and Osterix, are able to overcome some of the defects and inhibit tumor propagation through promoting osteogenic differentiation. Further understanding of the relationship between defects in osteogenic differentiation and tumor development holds tremendous potential in treating OS. Hindawi Publishing Corporation 2011 2011-02-22 /pmc/articles/PMC3061279/ /pubmed/21437219 http://dx.doi.org/10.1155/2011/325238 Text en Copyright © 2011 Eric R. Wagner et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Wagner, Eric R.
Luther, Gaurav
Zhu, Gaohui
Luo, Qing
Shi, Qiong
Kim, Stephanie H.
Gao, Jian-Li
Huang, Enyi
Gao, Yanhong
Yang, Ke
Wang, Linyuan
Teven, Chad
Luo, Xiaoji
Liu, Xing
Li, Mi
Hu, Ning
Su, Yuxi
Bi, Yang
He, Bai-Cheng
Tang, Ni
Luo, Jinyong
Chen, Liang
Zuo, Guowei
Rames, Richard
Haydon, Rex C.
Luu, Hue H.
He, Tong-Chuan
Defective Osteogenic Differentiation in the Development of Osteosarcoma
title Defective Osteogenic Differentiation in the Development of Osteosarcoma
title_full Defective Osteogenic Differentiation in the Development of Osteosarcoma
title_fullStr Defective Osteogenic Differentiation in the Development of Osteosarcoma
title_full_unstemmed Defective Osteogenic Differentiation in the Development of Osteosarcoma
title_short Defective Osteogenic Differentiation in the Development of Osteosarcoma
title_sort defective osteogenic differentiation in the development of osteosarcoma
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061279/
https://www.ncbi.nlm.nih.gov/pubmed/21437219
http://dx.doi.org/10.1155/2011/325238
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