Cargando…
Defective Osteogenic Differentiation in the Development of Osteosarcoma
Osteosarcoma (OS) is associated with poor prognosis due to its high incidence of metastasis and chemoresistance. It often arises in areas of rapid bone growth in long bones during the adolescent growth spurt. Although certain genetic conditions and alterations increase the risk of developing OS, the...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061279/ https://www.ncbi.nlm.nih.gov/pubmed/21437219 http://dx.doi.org/10.1155/2011/325238 |
_version_ | 1782200589175750656 |
---|---|
author | Wagner, Eric R. Luther, Gaurav Zhu, Gaohui Luo, Qing Shi, Qiong Kim, Stephanie H. Gao, Jian-Li Huang, Enyi Gao, Yanhong Yang, Ke Wang, Linyuan Teven, Chad Luo, Xiaoji Liu, Xing Li, Mi Hu, Ning Su, Yuxi Bi, Yang He, Bai-Cheng Tang, Ni Luo, Jinyong Chen, Liang Zuo, Guowei Rames, Richard Haydon, Rex C. Luu, Hue H. He, Tong-Chuan |
author_facet | Wagner, Eric R. Luther, Gaurav Zhu, Gaohui Luo, Qing Shi, Qiong Kim, Stephanie H. Gao, Jian-Li Huang, Enyi Gao, Yanhong Yang, Ke Wang, Linyuan Teven, Chad Luo, Xiaoji Liu, Xing Li, Mi Hu, Ning Su, Yuxi Bi, Yang He, Bai-Cheng Tang, Ni Luo, Jinyong Chen, Liang Zuo, Guowei Rames, Richard Haydon, Rex C. Luu, Hue H. He, Tong-Chuan |
author_sort | Wagner, Eric R. |
collection | PubMed |
description | Osteosarcoma (OS) is associated with poor prognosis due to its high incidence of metastasis and chemoresistance. It often arises in areas of rapid bone growth in long bones during the adolescent growth spurt. Although certain genetic conditions and alterations increase the risk of developing OS, the molecular pathogenesis is poorly understood. Recently, defects in differentiation have been linked to cancers, as they are associated with high cell proliferation. Treatments overcoming these defects enable terminal differentiation and subsequent tumor inhibition. OS development may be associated with defects in osteogenic differentiation. While early regulators of osteogenesis are unable to bypass these defects, late osteogenic regulators, including Runx2 and Osterix, are able to overcome some of the defects and inhibit tumor propagation through promoting osteogenic differentiation. Further understanding of the relationship between defects in osteogenic differentiation and tumor development holds tremendous potential in treating OS. |
format | Text |
id | pubmed-3061279 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-30612792011-03-24 Defective Osteogenic Differentiation in the Development of Osteosarcoma Wagner, Eric R. Luther, Gaurav Zhu, Gaohui Luo, Qing Shi, Qiong Kim, Stephanie H. Gao, Jian-Li Huang, Enyi Gao, Yanhong Yang, Ke Wang, Linyuan Teven, Chad Luo, Xiaoji Liu, Xing Li, Mi Hu, Ning Su, Yuxi Bi, Yang He, Bai-Cheng Tang, Ni Luo, Jinyong Chen, Liang Zuo, Guowei Rames, Richard Haydon, Rex C. Luu, Hue H. He, Tong-Chuan Sarcoma Review Article Osteosarcoma (OS) is associated with poor prognosis due to its high incidence of metastasis and chemoresistance. It often arises in areas of rapid bone growth in long bones during the adolescent growth spurt. Although certain genetic conditions and alterations increase the risk of developing OS, the molecular pathogenesis is poorly understood. Recently, defects in differentiation have been linked to cancers, as they are associated with high cell proliferation. Treatments overcoming these defects enable terminal differentiation and subsequent tumor inhibition. OS development may be associated with defects in osteogenic differentiation. While early regulators of osteogenesis are unable to bypass these defects, late osteogenic regulators, including Runx2 and Osterix, are able to overcome some of the defects and inhibit tumor propagation through promoting osteogenic differentiation. Further understanding of the relationship between defects in osteogenic differentiation and tumor development holds tremendous potential in treating OS. Hindawi Publishing Corporation 2011 2011-02-22 /pmc/articles/PMC3061279/ /pubmed/21437219 http://dx.doi.org/10.1155/2011/325238 Text en Copyright © 2011 Eric R. Wagner et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Wagner, Eric R. Luther, Gaurav Zhu, Gaohui Luo, Qing Shi, Qiong Kim, Stephanie H. Gao, Jian-Li Huang, Enyi Gao, Yanhong Yang, Ke Wang, Linyuan Teven, Chad Luo, Xiaoji Liu, Xing Li, Mi Hu, Ning Su, Yuxi Bi, Yang He, Bai-Cheng Tang, Ni Luo, Jinyong Chen, Liang Zuo, Guowei Rames, Richard Haydon, Rex C. Luu, Hue H. He, Tong-Chuan Defective Osteogenic Differentiation in the Development of Osteosarcoma |
title | Defective Osteogenic Differentiation in the Development of Osteosarcoma |
title_full | Defective Osteogenic Differentiation in the Development of Osteosarcoma |
title_fullStr | Defective Osteogenic Differentiation in the Development of Osteosarcoma |
title_full_unstemmed | Defective Osteogenic Differentiation in the Development of Osteosarcoma |
title_short | Defective Osteogenic Differentiation in the Development of Osteosarcoma |
title_sort | defective osteogenic differentiation in the development of osteosarcoma |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061279/ https://www.ncbi.nlm.nih.gov/pubmed/21437219 http://dx.doi.org/10.1155/2011/325238 |
work_keys_str_mv | AT wagnerericr defectiveosteogenicdifferentiationinthedevelopmentofosteosarcoma AT luthergaurav defectiveosteogenicdifferentiationinthedevelopmentofosteosarcoma AT zhugaohui defectiveosteogenicdifferentiationinthedevelopmentofosteosarcoma AT luoqing defectiveosteogenicdifferentiationinthedevelopmentofosteosarcoma AT shiqiong defectiveosteogenicdifferentiationinthedevelopmentofosteosarcoma AT kimstephanieh defectiveosteogenicdifferentiationinthedevelopmentofosteosarcoma AT gaojianli defectiveosteogenicdifferentiationinthedevelopmentofosteosarcoma AT huangenyi defectiveosteogenicdifferentiationinthedevelopmentofosteosarcoma AT gaoyanhong defectiveosteogenicdifferentiationinthedevelopmentofosteosarcoma AT yangke defectiveosteogenicdifferentiationinthedevelopmentofosteosarcoma AT wanglinyuan defectiveosteogenicdifferentiationinthedevelopmentofosteosarcoma AT tevenchad defectiveosteogenicdifferentiationinthedevelopmentofosteosarcoma AT luoxiaoji defectiveosteogenicdifferentiationinthedevelopmentofosteosarcoma AT liuxing defectiveosteogenicdifferentiationinthedevelopmentofosteosarcoma AT limi defectiveosteogenicdifferentiationinthedevelopmentofosteosarcoma AT huning defectiveosteogenicdifferentiationinthedevelopmentofosteosarcoma AT suyuxi defectiveosteogenicdifferentiationinthedevelopmentofosteosarcoma AT biyang defectiveosteogenicdifferentiationinthedevelopmentofosteosarcoma AT hebaicheng defectiveosteogenicdifferentiationinthedevelopmentofosteosarcoma AT tangni defectiveosteogenicdifferentiationinthedevelopmentofosteosarcoma AT luojinyong defectiveosteogenicdifferentiationinthedevelopmentofosteosarcoma AT chenliang defectiveosteogenicdifferentiationinthedevelopmentofosteosarcoma AT zuoguowei defectiveosteogenicdifferentiationinthedevelopmentofosteosarcoma AT ramesrichard defectiveosteogenicdifferentiationinthedevelopmentofosteosarcoma AT haydonrexc defectiveosteogenicdifferentiationinthedevelopmentofosteosarcoma AT luuhueh defectiveosteogenicdifferentiationinthedevelopmentofosteosarcoma AT hetongchuan defectiveosteogenicdifferentiationinthedevelopmentofosteosarcoma |