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Immune Suppression in Head and Neck Cancers: A Review
Head and neck squamous cell carcinomas (HNSCCs) are the sixth most common cancer in the world. Despite significant advances in the treatment modalities involving surgery, radiotherapy, and concomitant chemoradiotherapy, the 5-year survival rate remained below 50% for the past 30 years. The worse pro...
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061296/ https://www.ncbi.nlm.nih.gov/pubmed/21437225 http://dx.doi.org/10.1155/2010/701657 |
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author | Duray, Anaëlle Demoulin, Stéphanie Hubert, Pascale Delvenne, Philippe Saussez, Sven |
author_facet | Duray, Anaëlle Demoulin, Stéphanie Hubert, Pascale Delvenne, Philippe Saussez, Sven |
author_sort | Duray, Anaëlle |
collection | PubMed |
description | Head and neck squamous cell carcinomas (HNSCCs) are the sixth most common cancer in the world. Despite significant advances in the treatment modalities involving surgery, radiotherapy, and concomitant chemoradiotherapy, the 5-year survival rate remained below 50% for the past 30 years. The worse prognosis of these cancers must certainly be link to the fact that HNSCCs strongly influence the host immune system. We present a critical review of our understanding of the HNSCC escape to the antitumor immune response such as a downregulation of HLA class I and/or components of APM. Antitumor responses of HNSCC patients are compromised in the presence of functional defects or apoptosis of T-cells, both circulating and tumor-infiltrating. Langerhans cells are increased in the first steps of the carcinogenesis but decreased in invasive carcinomas. The accumulation of macrophages in the peritumoral areas seems to play a protumoral role by secreting VEGF and stimulating the neoangiogenesis. |
format | Text |
id | pubmed-3061296 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-30612962011-03-24 Immune Suppression in Head and Neck Cancers: A Review Duray, Anaëlle Demoulin, Stéphanie Hubert, Pascale Delvenne, Philippe Saussez, Sven Clin Dev Immunol Review Article Head and neck squamous cell carcinomas (HNSCCs) are the sixth most common cancer in the world. Despite significant advances in the treatment modalities involving surgery, radiotherapy, and concomitant chemoradiotherapy, the 5-year survival rate remained below 50% for the past 30 years. The worse prognosis of these cancers must certainly be link to the fact that HNSCCs strongly influence the host immune system. We present a critical review of our understanding of the HNSCC escape to the antitumor immune response such as a downregulation of HLA class I and/or components of APM. Antitumor responses of HNSCC patients are compromised in the presence of functional defects or apoptosis of T-cells, both circulating and tumor-infiltrating. Langerhans cells are increased in the first steps of the carcinogenesis but decreased in invasive carcinomas. The accumulation of macrophages in the peritumoral areas seems to play a protumoral role by secreting VEGF and stimulating the neoangiogenesis. Hindawi Publishing Corporation 2010 2011-03-10 /pmc/articles/PMC3061296/ /pubmed/21437225 http://dx.doi.org/10.1155/2010/701657 Text en Copyright © 2010 Anaëlle Duray et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Duray, Anaëlle Demoulin, Stéphanie Hubert, Pascale Delvenne, Philippe Saussez, Sven Immune Suppression in Head and Neck Cancers: A Review |
title | Immune Suppression in Head and Neck Cancers: A Review |
title_full | Immune Suppression in Head and Neck Cancers: A Review |
title_fullStr | Immune Suppression in Head and Neck Cancers: A Review |
title_full_unstemmed | Immune Suppression in Head and Neck Cancers: A Review |
title_short | Immune Suppression in Head and Neck Cancers: A Review |
title_sort | immune suppression in head and neck cancers: a review |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061296/ https://www.ncbi.nlm.nih.gov/pubmed/21437225 http://dx.doi.org/10.1155/2010/701657 |
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