Cargando…
Molecular Approach to Uterine Leiomyosarcoma: LMP2-Deficient Mice as an Animal Model of Spontaneous Uterine Leiomyosarcoma
Uterine leiomyosarcoma (LMS) develops more often in the muscle tissue layer of the uterine body than in the uterine cervix. The development of gynecologic tumors is often correlated with female hormone secretion; however, the development of uterine LMS is not substantially correlated with hormonal c...
Autores principales: | , , , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061316/ https://www.ncbi.nlm.nih.gov/pubmed/21437229 http://dx.doi.org/10.1155/2011/476498 |
_version_ | 1782200591962865664 |
---|---|
author | Hayashi, Takuma Horiuchi, Akiko Sano, Kenji Hiraoka, Nobuyoshi Kanai, Yae Shiozawa, Tanri Tonegawa, Susumu Konishi, Ikuo |
author_facet | Hayashi, Takuma Horiuchi, Akiko Sano, Kenji Hiraoka, Nobuyoshi Kanai, Yae Shiozawa, Tanri Tonegawa, Susumu Konishi, Ikuo |
author_sort | Hayashi, Takuma |
collection | PubMed |
description | Uterine leiomyosarcoma (LMS) develops more often in the muscle tissue layer of the uterine body than in the uterine cervix. The development of gynecologic tumors is often correlated with female hormone secretion; however, the development of uterine LMS is not substantially correlated with hormonal conditions, and the risk factors are not yet known. Importantly, a diagnostic-biomarker which distinguishes malignant LMS from benign tumor leiomyoma (LMA) is yet to be established. Accordingly, it is necessary to analyze risk factors associated with uterine LMS, in order to establish a treatment method. LMP2-deficient mice spontaneously develop uterine LMS, with a disease prevalence of ~40% by 14 months of age. We found LMP2 expression to be absent in human LMS, but present in human LMA. Therefore, defective LMP2 expression may be one of the risk factors for LMS. LMP2 is a potential diagnostic-biomarker for uterine LMS, and may be targeted-molecule for a new therapeutic approach. |
format | Text |
id | pubmed-3061316 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-30613162011-03-24 Molecular Approach to Uterine Leiomyosarcoma: LMP2-Deficient Mice as an Animal Model of Spontaneous Uterine Leiomyosarcoma Hayashi, Takuma Horiuchi, Akiko Sano, Kenji Hiraoka, Nobuyoshi Kanai, Yae Shiozawa, Tanri Tonegawa, Susumu Konishi, Ikuo Sarcoma Review Article Uterine leiomyosarcoma (LMS) develops more often in the muscle tissue layer of the uterine body than in the uterine cervix. The development of gynecologic tumors is often correlated with female hormone secretion; however, the development of uterine LMS is not substantially correlated with hormonal conditions, and the risk factors are not yet known. Importantly, a diagnostic-biomarker which distinguishes malignant LMS from benign tumor leiomyoma (LMA) is yet to be established. Accordingly, it is necessary to analyze risk factors associated with uterine LMS, in order to establish a treatment method. LMP2-deficient mice spontaneously develop uterine LMS, with a disease prevalence of ~40% by 14 months of age. We found LMP2 expression to be absent in human LMS, but present in human LMA. Therefore, defective LMP2 expression may be one of the risk factors for LMS. LMP2 is a potential diagnostic-biomarker for uterine LMS, and may be targeted-molecule for a new therapeutic approach. Hindawi Publishing Corporation 2011 2011-03-08 /pmc/articles/PMC3061316/ /pubmed/21437229 http://dx.doi.org/10.1155/2011/476498 Text en Copyright © 2011 Takuma Hayashi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Hayashi, Takuma Horiuchi, Akiko Sano, Kenji Hiraoka, Nobuyoshi Kanai, Yae Shiozawa, Tanri Tonegawa, Susumu Konishi, Ikuo Molecular Approach to Uterine Leiomyosarcoma: LMP2-Deficient Mice as an Animal Model of Spontaneous Uterine Leiomyosarcoma |
title | Molecular Approach to Uterine Leiomyosarcoma: LMP2-Deficient Mice
as an Animal Model of Spontaneous Uterine Leiomyosarcoma |
title_full | Molecular Approach to Uterine Leiomyosarcoma: LMP2-Deficient Mice
as an Animal Model of Spontaneous Uterine Leiomyosarcoma |
title_fullStr | Molecular Approach to Uterine Leiomyosarcoma: LMP2-Deficient Mice
as an Animal Model of Spontaneous Uterine Leiomyosarcoma |
title_full_unstemmed | Molecular Approach to Uterine Leiomyosarcoma: LMP2-Deficient Mice
as an Animal Model of Spontaneous Uterine Leiomyosarcoma |
title_short | Molecular Approach to Uterine Leiomyosarcoma: LMP2-Deficient Mice
as an Animal Model of Spontaneous Uterine Leiomyosarcoma |
title_sort | molecular approach to uterine leiomyosarcoma: lmp2-deficient mice
as an animal model of spontaneous uterine leiomyosarcoma |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061316/ https://www.ncbi.nlm.nih.gov/pubmed/21437229 http://dx.doi.org/10.1155/2011/476498 |
work_keys_str_mv | AT hayashitakuma molecularapproachtouterineleiomyosarcomalmp2deficientmiceasananimalmodelofspontaneousuterineleiomyosarcoma AT horiuchiakiko molecularapproachtouterineleiomyosarcomalmp2deficientmiceasananimalmodelofspontaneousuterineleiomyosarcoma AT sanokenji molecularapproachtouterineleiomyosarcomalmp2deficientmiceasananimalmodelofspontaneousuterineleiomyosarcoma AT hiraokanobuyoshi molecularapproachtouterineleiomyosarcomalmp2deficientmiceasananimalmodelofspontaneousuterineleiomyosarcoma AT kanaiyae molecularapproachtouterineleiomyosarcomalmp2deficientmiceasananimalmodelofspontaneousuterineleiomyosarcoma AT shiozawatanri molecularapproachtouterineleiomyosarcomalmp2deficientmiceasananimalmodelofspontaneousuterineleiomyosarcoma AT tonegawasusumu molecularapproachtouterineleiomyosarcomalmp2deficientmiceasananimalmodelofspontaneousuterineleiomyosarcoma AT konishiikuo molecularapproachtouterineleiomyosarcomalmp2deficientmiceasananimalmodelofspontaneousuterineleiomyosarcoma |