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Molecular Approach to Uterine Leiomyosarcoma: LMP2-Deficient Mice as an Animal Model of Spontaneous Uterine Leiomyosarcoma

Uterine leiomyosarcoma (LMS) develops more often in the muscle tissue layer of the uterine body than in the uterine cervix. The development of gynecologic tumors is often correlated with female hormone secretion; however, the development of uterine LMS is not substantially correlated with hormonal c...

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Autores principales: Hayashi, Takuma, Horiuchi, Akiko, Sano, Kenji, Hiraoka, Nobuyoshi, Kanai, Yae, Shiozawa, Tanri, Tonegawa, Susumu, Konishi, Ikuo
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061316/
https://www.ncbi.nlm.nih.gov/pubmed/21437229
http://dx.doi.org/10.1155/2011/476498
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author Hayashi, Takuma
Horiuchi, Akiko
Sano, Kenji
Hiraoka, Nobuyoshi
Kanai, Yae
Shiozawa, Tanri
Tonegawa, Susumu
Konishi, Ikuo
author_facet Hayashi, Takuma
Horiuchi, Akiko
Sano, Kenji
Hiraoka, Nobuyoshi
Kanai, Yae
Shiozawa, Tanri
Tonegawa, Susumu
Konishi, Ikuo
author_sort Hayashi, Takuma
collection PubMed
description Uterine leiomyosarcoma (LMS) develops more often in the muscle tissue layer of the uterine body than in the uterine cervix. The development of gynecologic tumors is often correlated with female hormone secretion; however, the development of uterine LMS is not substantially correlated with hormonal conditions, and the risk factors are not yet known. Importantly, a diagnostic-biomarker which distinguishes malignant LMS from benign tumor leiomyoma (LMA) is yet to be established. Accordingly, it is necessary to analyze risk factors associated with uterine LMS, in order to establish a treatment method. LMP2-deficient mice spontaneously develop uterine LMS, with a disease prevalence of ~40% by 14 months of age. We found LMP2 expression to be absent in human LMS, but present in human LMA. Therefore, defective LMP2 expression may be one of the risk factors for LMS. LMP2 is a potential diagnostic-biomarker for uterine LMS, and may be targeted-molecule for a new therapeutic approach.
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spelling pubmed-30613162011-03-24 Molecular Approach to Uterine Leiomyosarcoma: LMP2-Deficient Mice as an Animal Model of Spontaneous Uterine Leiomyosarcoma Hayashi, Takuma Horiuchi, Akiko Sano, Kenji Hiraoka, Nobuyoshi Kanai, Yae Shiozawa, Tanri Tonegawa, Susumu Konishi, Ikuo Sarcoma Review Article Uterine leiomyosarcoma (LMS) develops more often in the muscle tissue layer of the uterine body than in the uterine cervix. The development of gynecologic tumors is often correlated with female hormone secretion; however, the development of uterine LMS is not substantially correlated with hormonal conditions, and the risk factors are not yet known. Importantly, a diagnostic-biomarker which distinguishes malignant LMS from benign tumor leiomyoma (LMA) is yet to be established. Accordingly, it is necessary to analyze risk factors associated with uterine LMS, in order to establish a treatment method. LMP2-deficient mice spontaneously develop uterine LMS, with a disease prevalence of ~40% by 14 months of age. We found LMP2 expression to be absent in human LMS, but present in human LMA. Therefore, defective LMP2 expression may be one of the risk factors for LMS. LMP2 is a potential diagnostic-biomarker for uterine LMS, and may be targeted-molecule for a new therapeutic approach. Hindawi Publishing Corporation 2011 2011-03-08 /pmc/articles/PMC3061316/ /pubmed/21437229 http://dx.doi.org/10.1155/2011/476498 Text en Copyright © 2011 Takuma Hayashi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Hayashi, Takuma
Horiuchi, Akiko
Sano, Kenji
Hiraoka, Nobuyoshi
Kanai, Yae
Shiozawa, Tanri
Tonegawa, Susumu
Konishi, Ikuo
Molecular Approach to Uterine Leiomyosarcoma: LMP2-Deficient Mice as an Animal Model of Spontaneous Uterine Leiomyosarcoma
title Molecular Approach to Uterine Leiomyosarcoma: LMP2-Deficient Mice as an Animal Model of Spontaneous Uterine Leiomyosarcoma
title_full Molecular Approach to Uterine Leiomyosarcoma: LMP2-Deficient Mice as an Animal Model of Spontaneous Uterine Leiomyosarcoma
title_fullStr Molecular Approach to Uterine Leiomyosarcoma: LMP2-Deficient Mice as an Animal Model of Spontaneous Uterine Leiomyosarcoma
title_full_unstemmed Molecular Approach to Uterine Leiomyosarcoma: LMP2-Deficient Mice as an Animal Model of Spontaneous Uterine Leiomyosarcoma
title_short Molecular Approach to Uterine Leiomyosarcoma: LMP2-Deficient Mice as an Animal Model of Spontaneous Uterine Leiomyosarcoma
title_sort molecular approach to uterine leiomyosarcoma: lmp2-deficient mice as an animal model of spontaneous uterine leiomyosarcoma
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061316/
https://www.ncbi.nlm.nih.gov/pubmed/21437229
http://dx.doi.org/10.1155/2011/476498
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