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Longitudinal study of Cystatin C in healthy term newborns
OBJECTIVE: The purpose of this study was to determine the levels of Cystatin C in healthy term newborns in the first month of life. INTRODUCTION: Cystatin C may be a suitable marker for determining the glomerular filtration rate because it is not affected by maternal renal function. METHODS: Cohort...
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Formato: | Texto |
Lenguaje: | English |
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Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061410/ https://www.ncbi.nlm.nih.gov/pubmed/21484036 http://dx.doi.org/10.1590/S1807-59322011000200006 |
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author | de Albuquerque Cavalcanti Ferreira Novo, Ana Carolina dos Santos Rodrigues Sadeck, Lílian Okay, Thelma Suely Leone, Cléa Rodrigues |
author_facet | de Albuquerque Cavalcanti Ferreira Novo, Ana Carolina dos Santos Rodrigues Sadeck, Lílian Okay, Thelma Suely Leone, Cléa Rodrigues |
author_sort | de Albuquerque Cavalcanti Ferreira Novo, Ana Carolina |
collection | PubMed |
description | OBJECTIVE: The purpose of this study was to determine the levels of Cystatin C in healthy term newborns in the first month of life. INTRODUCTION: Cystatin C may be a suitable marker for determining the glomerular filtration rate because it is not affected by maternal renal function. METHODS: Cohort study. Inclusion: term newborns with appropriate weight; mother without renal failure or drugs that could affect fetal glomerular filtration rate. Exclusion: malformations; hypertension or any condition that could affect glomerular filtration rate. Cystatin C (mg/L) and creatinine (mg/dl) were determined in the mother (Mo) and in the newborn at birth (Day‐0), 3(rd) (Day‐3), 7(th)(Day‐7) and 28(th)(Day‐28) days. Statistics: one way ANOVA and Pearson's correlation tests. Sample size of 20 subjects for α = 5% and a power test = 80% (p<0.05). RESULTS: Data from 21 newborns were obtained (mean ± standard deviation): MoCystatin C = 1.00±0.20; Day‐0 Cystatin C 1.70±0.26; Day‐3 Cystatin C = 1.51±0.20; Day‐7 Cystatin C = 1.54±0.10; Day‐28 Cystatin C = 1.51±0.10. MoCystatin C was smaller than Day‐0 Cystatin C (p<0.001), while MoCreatinine was not different from Day‐0 Creatinine. Cystatin C only decreased from Day‐0 to Day‐3 (p = 0.004) but newborns Creatinine decreased along the time. Correlations were obtained between MoCystatin C and MoCreatinine (p = 0.012), as well as Day‐3 (p = 0.047) and Day‐28 (p = 0.022) Cystatin C and Creatinine values. CONCLUSION: Neonatal Cystatin C values were not affected by MoCystatin C and became stable from the 3(rd) day of life. |
format | Text |
id | pubmed-3061410 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo |
record_format | MEDLINE/PubMed |
spelling | pubmed-30614102011-03-21 Longitudinal study of Cystatin C in healthy term newborns de Albuquerque Cavalcanti Ferreira Novo, Ana Carolina dos Santos Rodrigues Sadeck, Lílian Okay, Thelma Suely Leone, Cléa Rodrigues Clinics (Sao Paulo) Clinical Science OBJECTIVE: The purpose of this study was to determine the levels of Cystatin C in healthy term newborns in the first month of life. INTRODUCTION: Cystatin C may be a suitable marker for determining the glomerular filtration rate because it is not affected by maternal renal function. METHODS: Cohort study. Inclusion: term newborns with appropriate weight; mother without renal failure or drugs that could affect fetal glomerular filtration rate. Exclusion: malformations; hypertension or any condition that could affect glomerular filtration rate. Cystatin C (mg/L) and creatinine (mg/dl) were determined in the mother (Mo) and in the newborn at birth (Day‐0), 3(rd) (Day‐3), 7(th)(Day‐7) and 28(th)(Day‐28) days. Statistics: one way ANOVA and Pearson's correlation tests. Sample size of 20 subjects for α = 5% and a power test = 80% (p<0.05). RESULTS: Data from 21 newborns were obtained (mean ± standard deviation): MoCystatin C = 1.00±0.20; Day‐0 Cystatin C 1.70±0.26; Day‐3 Cystatin C = 1.51±0.20; Day‐7 Cystatin C = 1.54±0.10; Day‐28 Cystatin C = 1.51±0.10. MoCystatin C was smaller than Day‐0 Cystatin C (p<0.001), while MoCreatinine was not different from Day‐0 Creatinine. Cystatin C only decreased from Day‐0 to Day‐3 (p = 0.004) but newborns Creatinine decreased along the time. Correlations were obtained between MoCystatin C and MoCreatinine (p = 0.012), as well as Day‐3 (p = 0.047) and Day‐28 (p = 0.022) Cystatin C and Creatinine values. CONCLUSION: Neonatal Cystatin C values were not affected by MoCystatin C and became stable from the 3(rd) day of life. Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2011-02 /pmc/articles/PMC3061410/ /pubmed/21484036 http://dx.doi.org/10.1590/S1807-59322011000200006 Text en Copyright © 2011 Hospital das Clínicas da FMUSP http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Science de Albuquerque Cavalcanti Ferreira Novo, Ana Carolina dos Santos Rodrigues Sadeck, Lílian Okay, Thelma Suely Leone, Cléa Rodrigues Longitudinal study of Cystatin C in healthy term newborns |
title | Longitudinal study of Cystatin C in healthy term newborns |
title_full | Longitudinal study of Cystatin C in healthy term newborns |
title_fullStr | Longitudinal study of Cystatin C in healthy term newborns |
title_full_unstemmed | Longitudinal study of Cystatin C in healthy term newborns |
title_short | Longitudinal study of Cystatin C in healthy term newborns |
title_sort | longitudinal study of cystatin c in healthy term newborns |
topic | Clinical Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061410/ https://www.ncbi.nlm.nih.gov/pubmed/21484036 http://dx.doi.org/10.1590/S1807-59322011000200006 |
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