Titanium Salan Complexes Displays Strong Antitumor Properties In Vitro and In Vivo in Mice

The anticancer activity of titanium complexes has been known since the groundbreaking studies of Köpf and Köpf-Maier on titanocen dichloride. Unfortunately, possibly due to their fast hydrolysis, derivatives of titanocen dichloride failed in clinical studies. Recently, the new family of titanium sal...

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Detalles Bibliográficos
Autores principales: Immel, Timo A., Groth, Ulrich, Huhn, Thomas, Öhlschläger, Peter
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061874/
https://www.ncbi.nlm.nih.gov/pubmed/21445304
http://dx.doi.org/10.1371/journal.pone.0017869
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author Immel, Timo A.
Groth, Ulrich
Huhn, Thomas
Öhlschläger, Peter
author_facet Immel, Timo A.
Groth, Ulrich
Huhn, Thomas
Öhlschläger, Peter
author_sort Immel, Timo A.
collection PubMed
description The anticancer activity of titanium complexes has been known since the groundbreaking studies of Köpf and Köpf-Maier on titanocen dichloride. Unfortunately, possibly due to their fast hydrolysis, derivatives of titanocen dichloride failed in clinical studies. Recently, the new family of titanium salan complexes containing tetradentate ONNO ligands with anti-cancer properties has been discovered. These salan complexes are much more stabile in aqueous media. In this study we describe the biological activity of two titanium salan complexes in a mouse model of cervical cancer. High efficiency of this promising complex family was demonstrated for the first time in vivo. From these data we conclude that titanium salan complexes display very strong antitumor properties exhibiting only minor side effects. Our results may influence the chemotherapy with metallo therapeutics in the future.
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spelling pubmed-30618742011-03-28 Titanium Salan Complexes Displays Strong Antitumor Properties In Vitro and In Vivo in Mice Immel, Timo A. Groth, Ulrich Huhn, Thomas Öhlschläger, Peter PLoS One Research Article The anticancer activity of titanium complexes has been known since the groundbreaking studies of Köpf and Köpf-Maier on titanocen dichloride. Unfortunately, possibly due to their fast hydrolysis, derivatives of titanocen dichloride failed in clinical studies. Recently, the new family of titanium salan complexes containing tetradentate ONNO ligands with anti-cancer properties has been discovered. These salan complexes are much more stabile in aqueous media. In this study we describe the biological activity of two titanium salan complexes in a mouse model of cervical cancer. High efficiency of this promising complex family was demonstrated for the first time in vivo. From these data we conclude that titanium salan complexes display very strong antitumor properties exhibiting only minor side effects. Our results may influence the chemotherapy with metallo therapeutics in the future. Public Library of Science 2011-03-21 /pmc/articles/PMC3061874/ /pubmed/21445304 http://dx.doi.org/10.1371/journal.pone.0017869 Text en Öhlschläger et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Immel, Timo A.
Groth, Ulrich
Huhn, Thomas
Öhlschläger, Peter
Titanium Salan Complexes Displays Strong Antitumor Properties In Vitro and In Vivo in Mice
title Titanium Salan Complexes Displays Strong Antitumor Properties In Vitro and In Vivo in Mice
title_full Titanium Salan Complexes Displays Strong Antitumor Properties In Vitro and In Vivo in Mice
title_fullStr Titanium Salan Complexes Displays Strong Antitumor Properties In Vitro and In Vivo in Mice
title_full_unstemmed Titanium Salan Complexes Displays Strong Antitumor Properties In Vitro and In Vivo in Mice
title_short Titanium Salan Complexes Displays Strong Antitumor Properties In Vitro and In Vivo in Mice
title_sort titanium salan complexes displays strong antitumor properties in vitro and in vivo in mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061874/
https://www.ncbi.nlm.nih.gov/pubmed/21445304
http://dx.doi.org/10.1371/journal.pone.0017869
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AT ohlschlagerpeter titaniumsalancomplexesdisplaysstrongantitumorpropertiesinvitroandinvivoinmice

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