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Regulation of AKT Phosphorylation at Ser473 and Thr308 by Endoplasmic Reticulum Stress Modulates Substrate Specificity in a Severity Dependent Manner

Endoplasmic reticulum (ER) stress is a common factor in the pathophysiology of diverse human diseases that are characterised by contrasting cellular behaviours, from proliferation in cancer to apoptosis in neurodegenerative disorders. Coincidently, dysregulation of AKT/PKB activity, which is the cen...

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Detalles Bibliográficos
Autores principales:	Yung, Hong Wa, Charnock-Jones, D. Stephen, Burton, Graham J.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061875/ https://www.ncbi.nlm.nih.gov/pubmed/21445305 http://dx.doi.org/10.1371/journal.pone.0017894

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