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Cortical swallowing processing in early subacute stroke
BACKGROUND: Dysphagia is a major complication in hemispheric as well as brainstem stroke patients causing aspiration pneumonia and increased mortality. Little is known about the recovery from dysphagia after stroke. The aim of the present study was to determine the different patterns of cortical swa...
Autores principales: | , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061896/ https://www.ncbi.nlm.nih.gov/pubmed/21392404 http://dx.doi.org/10.1186/1471-2377-11-34 |
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author | Teismann, Inga K Suntrup, Sonja Warnecke, Tobias Steinsträter, Olaf Fischer, Maren Flöel, Agnes Ringelstein, E Bernd Pantev, Christo Dziewas, Rainer |
author_facet | Teismann, Inga K Suntrup, Sonja Warnecke, Tobias Steinsträter, Olaf Fischer, Maren Flöel, Agnes Ringelstein, E Bernd Pantev, Christo Dziewas, Rainer |
author_sort | Teismann, Inga K |
collection | PubMed |
description | BACKGROUND: Dysphagia is a major complication in hemispheric as well as brainstem stroke patients causing aspiration pneumonia and increased mortality. Little is known about the recovery from dysphagia after stroke. The aim of the present study was to determine the different patterns of cortical swallowing processing in patients with hemispheric and brainstem stroke with and without dysphagia in the early subacute phase. METHODS: We measured brain activity by mean of whole-head MEG in 37 patients with different stroke localisation 8.2 +/- 4.8 days after stroke to study changes in cortical activation during self-paced swallowing. An age matched group of healthy subjects served as controls. Data were analyzed by means of synthetic aperture magnetometry and group analyses were performed using a permutation test. RESULTS: Our results demonstrate strong bilateral reduction of cortical swallowing activation in dysphagic patients with hemispheric stroke. In hemispheric stroke without dysphagia, bilateral activation was found. In the small group of patients with brainstem stroke we observed a reduction of cortical activation and a right hemispheric lateralization. CONCLUSION: Bulbar central pattern generators coordinate the pharyngeal swallowing phase. The observed right hemispheric lateralization in brainstem stroke can therefore be interpreted as acute cortical compensation of subcortically caused dysphagia. The reduction of activation in brainstem stroke patients and dysphagic patients with cortical stroke could be explained in terms of diaschisis. |
format | Text |
id | pubmed-3061896 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-30618962011-03-22 Cortical swallowing processing in early subacute stroke Teismann, Inga K Suntrup, Sonja Warnecke, Tobias Steinsträter, Olaf Fischer, Maren Flöel, Agnes Ringelstein, E Bernd Pantev, Christo Dziewas, Rainer BMC Neurol Research Article BACKGROUND: Dysphagia is a major complication in hemispheric as well as brainstem stroke patients causing aspiration pneumonia and increased mortality. Little is known about the recovery from dysphagia after stroke. The aim of the present study was to determine the different patterns of cortical swallowing processing in patients with hemispheric and brainstem stroke with and without dysphagia in the early subacute phase. METHODS: We measured brain activity by mean of whole-head MEG in 37 patients with different stroke localisation 8.2 +/- 4.8 days after stroke to study changes in cortical activation during self-paced swallowing. An age matched group of healthy subjects served as controls. Data were analyzed by means of synthetic aperture magnetometry and group analyses were performed using a permutation test. RESULTS: Our results demonstrate strong bilateral reduction of cortical swallowing activation in dysphagic patients with hemispheric stroke. In hemispheric stroke without dysphagia, bilateral activation was found. In the small group of patients with brainstem stroke we observed a reduction of cortical activation and a right hemispheric lateralization. CONCLUSION: Bulbar central pattern generators coordinate the pharyngeal swallowing phase. The observed right hemispheric lateralization in brainstem stroke can therefore be interpreted as acute cortical compensation of subcortically caused dysphagia. The reduction of activation in brainstem stroke patients and dysphagic patients with cortical stroke could be explained in terms of diaschisis. BioMed Central 2011-03-11 /pmc/articles/PMC3061896/ /pubmed/21392404 http://dx.doi.org/10.1186/1471-2377-11-34 Text en Copyright ©2011 Teismann et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Teismann, Inga K Suntrup, Sonja Warnecke, Tobias Steinsträter, Olaf Fischer, Maren Flöel, Agnes Ringelstein, E Bernd Pantev, Christo Dziewas, Rainer Cortical swallowing processing in early subacute stroke |
title | Cortical swallowing processing in early subacute stroke |
title_full | Cortical swallowing processing in early subacute stroke |
title_fullStr | Cortical swallowing processing in early subacute stroke |
title_full_unstemmed | Cortical swallowing processing in early subacute stroke |
title_short | Cortical swallowing processing in early subacute stroke |
title_sort | cortical swallowing processing in early subacute stroke |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061896/ https://www.ncbi.nlm.nih.gov/pubmed/21392404 http://dx.doi.org/10.1186/1471-2377-11-34 |
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