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Brain cancer and pesticide relationship in orchard farmers of Kashmir

BACKGROUND: The increasing trend in the incidence of primary malignant brain tumors in orchard farmers and their families in Kashmir. AIM: To determine the relationship between the patients of primary malignant brain tumors and their occupation. MATERIALS AND METHODS: Retrospectively, case files alo...

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Autores principales: Bhat, Abdul Rashid, Wani, Muhammed Afzal, Kirmani, A. R.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062019/
https://www.ncbi.nlm.nih.gov/pubmed/21461159
http://dx.doi.org/10.4103/0019-5278.75694
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author Bhat, Abdul Rashid
Wani, Muhammed Afzal
Kirmani, A. R.
author_facet Bhat, Abdul Rashid
Wani, Muhammed Afzal
Kirmani, A. R.
author_sort Bhat, Abdul Rashid
collection PubMed
description BACKGROUND: The increasing trend in the incidence of primary malignant brain tumors in orchard farmers and their families in Kashmir. AIM: To determine the relationship between the patients of primary malignant brain tumors and their occupation. MATERIALS AND METHODS: Retrospectively, case files along with death certificates of 432 patients of primary malignant brain tumors and 457 controls (non-tumor neurologic diseases), admitted for treatment simultaneously over a period of 4 years from January 2005 to December 2008, to the Neurosurgery, Sher-i-Kashmir Institute of Medical Sciences (SKIMS), Kashmir, were studied. Follow-up and family interaction was established. RESULTS: Analysis revealed that 90.04% (389 out of 432) patients were orchard farm workers, orchard residents and orchard playing children exposed to the high levels of multiple types of neurotoxic and carcinogenic (chlorpyriphos, dimethoate, mancozeb and captan) chemicals for more than 10 years [relative risk (RR) = 10.6; odds ratio (OR) = >10; 95% confidence interval (CI) = >25-40]. The 9.96% (43 out of 432) patients were not exposed to pesticides. On the other hand, only 19 patients out of 457 controls had recorded history of pesticide exposure and 438 were unrelated to pesticides. Out of 389 patients, 71.7% (279 out of 389) were males and 28.3% (110 out of 389), including six members of three families, were females (one male child). CONCLUSION: All orchard-related 389 patients had high-grade tumors as compared to the non-pesticide tumors. Mortality in pesticide-exposed tumors was 12%. The higher or upper-normal levels of serum cholinesterase (AChE) were observed in 54.7% (213 out of 389) patients and decreased levels were found in only 45.3% (176 out of 389) orchard-related patients (RR = 19.4; OR = >5; 95% CI = >1-10). Although serum AChE levels were a routine investigation in malignant brain tumors, this was not a routine in other neurological conditions (hospitalized controls). The familial gliomas have shown an emerging trend in the orchard residents of valley of Kashmir.
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spelling pubmed-30620192011-04-01 Brain cancer and pesticide relationship in orchard farmers of Kashmir Bhat, Abdul Rashid Wani, Muhammed Afzal Kirmani, A. R. Indian J Occup Environ Med Original Article BACKGROUND: The increasing trend in the incidence of primary malignant brain tumors in orchard farmers and their families in Kashmir. AIM: To determine the relationship between the patients of primary malignant brain tumors and their occupation. MATERIALS AND METHODS: Retrospectively, case files along with death certificates of 432 patients of primary malignant brain tumors and 457 controls (non-tumor neurologic diseases), admitted for treatment simultaneously over a period of 4 years from January 2005 to December 2008, to the Neurosurgery, Sher-i-Kashmir Institute of Medical Sciences (SKIMS), Kashmir, were studied. Follow-up and family interaction was established. RESULTS: Analysis revealed that 90.04% (389 out of 432) patients were orchard farm workers, orchard residents and orchard playing children exposed to the high levels of multiple types of neurotoxic and carcinogenic (chlorpyriphos, dimethoate, mancozeb and captan) chemicals for more than 10 years [relative risk (RR) = 10.6; odds ratio (OR) = >10; 95% confidence interval (CI) = >25-40]. The 9.96% (43 out of 432) patients were not exposed to pesticides. On the other hand, only 19 patients out of 457 controls had recorded history of pesticide exposure and 438 were unrelated to pesticides. Out of 389 patients, 71.7% (279 out of 389) were males and 28.3% (110 out of 389), including six members of three families, were females (one male child). CONCLUSION: All orchard-related 389 patients had high-grade tumors as compared to the non-pesticide tumors. Mortality in pesticide-exposed tumors was 12%. The higher or upper-normal levels of serum cholinesterase (AChE) were observed in 54.7% (213 out of 389) patients and decreased levels were found in only 45.3% (176 out of 389) orchard-related patients (RR = 19.4; OR = >5; 95% CI = >1-10). Although serum AChE levels were a routine investigation in malignant brain tumors, this was not a routine in other neurological conditions (hospitalized controls). The familial gliomas have shown an emerging trend in the orchard residents of valley of Kashmir. Medknow Publications 2010 /pmc/articles/PMC3062019/ /pubmed/21461159 http://dx.doi.org/10.4103/0019-5278.75694 Text en © Indian Journal of Occupational and Environmental Medicine http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Bhat, Abdul Rashid
Wani, Muhammed Afzal
Kirmani, A. R.
Brain cancer and pesticide relationship in orchard farmers of Kashmir
title Brain cancer and pesticide relationship in orchard farmers of Kashmir
title_full Brain cancer and pesticide relationship in orchard farmers of Kashmir
title_fullStr Brain cancer and pesticide relationship in orchard farmers of Kashmir
title_full_unstemmed Brain cancer and pesticide relationship in orchard farmers of Kashmir
title_short Brain cancer and pesticide relationship in orchard farmers of Kashmir
title_sort brain cancer and pesticide relationship in orchard farmers of kashmir
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062019/
https://www.ncbi.nlm.nih.gov/pubmed/21461159
http://dx.doi.org/10.4103/0019-5278.75694
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