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Relation of Subjective Quality of Life to Motor Symptom Profile in Parkinson's Disease

Parkinson's disease (PD) presents with extensive heterogeneity in symptomatology, inviting examination of disease subtypes. One significant categorization is by whether patients present at onset with tremor as the dominant symptom (TD) or with nontremor symptoms (NTD). We examined differences i...

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Autores principales: Appleman, Erica R., Stavitsky, Karina, Cronin-Golomb, Alice
Formato: Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062095/
https://www.ncbi.nlm.nih.gov/pubmed/21437183
http://dx.doi.org/10.4061/2011/472830
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author Appleman, Erica R.
Stavitsky, Karina
Cronin-Golomb, Alice
author_facet Appleman, Erica R.
Stavitsky, Karina
Cronin-Golomb, Alice
author_sort Appleman, Erica R.
collection PubMed
description Parkinson's disease (PD) presents with extensive heterogeneity in symptomatology, inviting examination of disease subtypes. One significant categorization is by whether patients present at onset with tremor as the dominant symptom (TD) or with nontremor symptoms (NTD). We examined differences in quality of life between TD and NTD patients using the Parkinson's Disease Questionnaire-39 (PDQ-39), correlating performance with aspects of motor function as indexed by the Unified Parkinson's Disease Rating Scale (UPDRS). Participants included 35 nondemented individuals (19 TD, 16 NTD) matched on clinical and demographic characteristics. NTD had significantly lower overall PDQ-39 scores, particularly for the mobility subscale. Several UPDRS subscale scores significantly correlated with quality of life, especially for NTD. Further, the correlations were driven by nontremor type symptoms, even in TD patients. Determining reliable subtypes of PD may aid in prognosis and treatment optimization, thereby enhancing quality of life in afflicted individuals.
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spelling pubmed-30620952011-03-24 Relation of Subjective Quality of Life to Motor Symptom Profile in Parkinson's Disease Appleman, Erica R. Stavitsky, Karina Cronin-Golomb, Alice Parkinsons Dis Research Article Parkinson's disease (PD) presents with extensive heterogeneity in symptomatology, inviting examination of disease subtypes. One significant categorization is by whether patients present at onset with tremor as the dominant symptom (TD) or with nontremor symptoms (NTD). We examined differences in quality of life between TD and NTD patients using the Parkinson's Disease Questionnaire-39 (PDQ-39), correlating performance with aspects of motor function as indexed by the Unified Parkinson's Disease Rating Scale (UPDRS). Participants included 35 nondemented individuals (19 TD, 16 NTD) matched on clinical and demographic characteristics. NTD had significantly lower overall PDQ-39 scores, particularly for the mobility subscale. Several UPDRS subscale scores significantly correlated with quality of life, especially for NTD. Further, the correlations were driven by nontremor type symptoms, even in TD patients. Determining reliable subtypes of PD may aid in prognosis and treatment optimization, thereby enhancing quality of life in afflicted individuals. SAGE-Hindawi Access to Research 2011-03-07 /pmc/articles/PMC3062095/ /pubmed/21437183 http://dx.doi.org/10.4061/2011/472830 Text en Copyright © 2011 Erica R. Appleman et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Appleman, Erica R.
Stavitsky, Karina
Cronin-Golomb, Alice
Relation of Subjective Quality of Life to Motor Symptom Profile in Parkinson's Disease
title Relation of Subjective Quality of Life to Motor Symptom Profile in Parkinson's Disease
title_full Relation of Subjective Quality of Life to Motor Symptom Profile in Parkinson's Disease
title_fullStr Relation of Subjective Quality of Life to Motor Symptom Profile in Parkinson's Disease
title_full_unstemmed Relation of Subjective Quality of Life to Motor Symptom Profile in Parkinson's Disease
title_short Relation of Subjective Quality of Life to Motor Symptom Profile in Parkinson's Disease
title_sort relation of subjective quality of life to motor symptom profile in parkinson's disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062095/
https://www.ncbi.nlm.nih.gov/pubmed/21437183
http://dx.doi.org/10.4061/2011/472830
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