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AIDS-Related EBV-Associated Smooth Muscle Tumors: A Review of 64 Published Cases

The number of reported cases of smooth muscle tumor (SMT) arising in patients with AIDS has been increasing since the mid-1990s. The aim of this study is to characterize the epidemiology, clinical manifestations, pathologic features, prognosis and, management of Epstein-Barr virus-related SMT (EBV-S...

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Autores principales: Purgina, Bibianna, Rao, Uma N. M., Miettinen, Markku, Pantanowitz, Liron
Formato: Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062098/
https://www.ncbi.nlm.nih.gov/pubmed/21437186
http://dx.doi.org/10.4061/2011/561548
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author Purgina, Bibianna
Rao, Uma N. M.
Miettinen, Markku
Pantanowitz, Liron
author_facet Purgina, Bibianna
Rao, Uma N. M.
Miettinen, Markku
Pantanowitz, Liron
author_sort Purgina, Bibianna
collection PubMed
description The number of reported cases of smooth muscle tumor (SMT) arising in patients with AIDS has been increasing since the mid-1990s. The aim of this study is to characterize the epidemiology, clinical manifestations, pathologic features, prognosis and, management of Epstein-Barr virus-related SMT (EBV-SMT) in patients with AIDS. An English language literature search identified 53 articles including 64 reported cases of EBV-SMT. The majority of these reports involved patients who were young, severely immunosuppressed, and had multifocal tumors. The central nervous system was the most common site to be involved. Histologically, tumors had smooth muscle features and were immunoreactive for muscle markers and all but two tumors demonstrated the presence of EBV by either immunohistochemistry, in situ hybridization, and/or PCR. While mitoses and/or necrosis were used to separate leiomyoma from leiomyosarcoma, these features did not correlate with clinical outcome. Treatment included primarily resection, and less often radiotherapy, chemotherapy and highly active antiretroviral therapy (HAART). Overall, EBV-SMTs appear to have variable aggressiveness and clinical outcome and may exhibit a more favorable prognosis compared to conventional leiomyosarcoma. Tumor-related death from EBV-SMT occurred in only 4 of 51 patients.
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spelling pubmed-30620982011-03-24 AIDS-Related EBV-Associated Smooth Muscle Tumors: A Review of 64 Published Cases Purgina, Bibianna Rao, Uma N. M. Miettinen, Markku Pantanowitz, Liron Patholog Res Int Review Article The number of reported cases of smooth muscle tumor (SMT) arising in patients with AIDS has been increasing since the mid-1990s. The aim of this study is to characterize the epidemiology, clinical manifestations, pathologic features, prognosis and, management of Epstein-Barr virus-related SMT (EBV-SMT) in patients with AIDS. An English language literature search identified 53 articles including 64 reported cases of EBV-SMT. The majority of these reports involved patients who were young, severely immunosuppressed, and had multifocal tumors. The central nervous system was the most common site to be involved. Histologically, tumors had smooth muscle features and were immunoreactive for muscle markers and all but two tumors demonstrated the presence of EBV by either immunohistochemistry, in situ hybridization, and/or PCR. While mitoses and/or necrosis were used to separate leiomyoma from leiomyosarcoma, these features did not correlate with clinical outcome. Treatment included primarily resection, and less often radiotherapy, chemotherapy and highly active antiretroviral therapy (HAART). Overall, EBV-SMTs appear to have variable aggressiveness and clinical outcome and may exhibit a more favorable prognosis compared to conventional leiomyosarcoma. Tumor-related death from EBV-SMT occurred in only 4 of 51 patients. SAGE-Hindawi Access to Research 2011-03-10 /pmc/articles/PMC3062098/ /pubmed/21437186 http://dx.doi.org/10.4061/2011/561548 Text en Copyright © 2011 Bibianna Purgina et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Purgina, Bibianna
Rao, Uma N. M.
Miettinen, Markku
Pantanowitz, Liron
AIDS-Related EBV-Associated Smooth Muscle Tumors: A Review of 64 Published Cases
title AIDS-Related EBV-Associated Smooth Muscle Tumors: A Review of 64 Published Cases
title_full AIDS-Related EBV-Associated Smooth Muscle Tumors: A Review of 64 Published Cases
title_fullStr AIDS-Related EBV-Associated Smooth Muscle Tumors: A Review of 64 Published Cases
title_full_unstemmed AIDS-Related EBV-Associated Smooth Muscle Tumors: A Review of 64 Published Cases
title_short AIDS-Related EBV-Associated Smooth Muscle Tumors: A Review of 64 Published Cases
title_sort aids-related ebv-associated smooth muscle tumors: a review of 64 published cases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062098/
https://www.ncbi.nlm.nih.gov/pubmed/21437186
http://dx.doi.org/10.4061/2011/561548
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