Ranitidine-induced thrombocytopenia: A rare drug reaction

H(2) antagonist ranitidine causing thrombocytopenia is a rare drug phenomenon. Here we present a case of 55 year old female of pustular psoriasis who presented with fever and vomiting. Patient. was started on roxithromycin, iv ondensetron, paracetamol and iv ranitidine. Complete blood count revealed...

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Detalles Bibliográficos
Autores principales: Bangia, Amit V, Kamath, Narendra, Mohan, Vidushi
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2011
Materias:
Drug Watch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062128/
https://www.ncbi.nlm.nih.gov/pubmed/21455428
http://dx.doi.org/10.4103/0253-7613.75676
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author Bangia, Amit V
Kamath, Narendra
Mohan, Vidushi
author_facet Bangia, Amit V
Kamath, Narendra
Mohan, Vidushi
author_sort Bangia, Amit V
collection PubMed
description H(2) antagonist ranitidine causing thrombocytopenia is a rare drug phenomenon. Here we present a case of 55 year old female of pustular psoriasis who presented with fever and vomiting. Patient. was started on roxithromycin, iv ondensetron, paracetamol and iv ranitidine. Complete blood count revealed neutrophilia with normal blood picture. However repeat investigations showed falling WBC and platelet count. After excluding other causes of pancytopenia we concluded that ranitidine was the cause for this atypical drug reaction, more so when the blood picture improved within 72 hrs of ranitidine withdrawal.
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spelling pubmed-30621282011-03-31 Ranitidine-induced thrombocytopenia: A rare drug reaction Bangia, Amit V Kamath, Narendra Mohan, Vidushi Indian J Pharmacol Drug Watch H(2) antagonist ranitidine causing thrombocytopenia is a rare drug phenomenon. Here we present a case of 55 year old female of pustular psoriasis who presented with fever and vomiting. Patient. was started on roxithromycin, iv ondensetron, paracetamol and iv ranitidine. Complete blood count revealed neutrophilia with normal blood picture. However repeat investigations showed falling WBC and platelet count. After excluding other causes of pancytopenia we concluded that ranitidine was the cause for this atypical drug reaction, more so when the blood picture improved within 72 hrs of ranitidine withdrawal. Medknow Publications 2011-02 /pmc/articles/PMC3062128/ /pubmed/21455428 http://dx.doi.org/10.4103/0253-7613.75676 Text en © Indian Journal of Pharmacology http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Drug Watch
Bangia, Amit V
Kamath, Narendra
Mohan, Vidushi
Ranitidine-induced thrombocytopenia: A rare drug reaction
title Ranitidine-induced thrombocytopenia: A rare drug reaction
title_full Ranitidine-induced thrombocytopenia: A rare drug reaction
title_fullStr Ranitidine-induced thrombocytopenia: A rare drug reaction
title_full_unstemmed Ranitidine-induced thrombocytopenia: A rare drug reaction
title_short Ranitidine-induced thrombocytopenia: A rare drug reaction
title_sort ranitidine-induced thrombocytopenia: a rare drug reaction
topic Drug Watch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062128/
https://www.ncbi.nlm.nih.gov/pubmed/21455428
http://dx.doi.org/10.4103/0253-7613.75676
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AT kamathnarendra ranitidineinducedthrombocytopeniaararedrugreaction
AT mohanvidushi ranitidineinducedthrombocytopeniaararedrugreaction

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