N-Acetylcysteine and N-Nitroarginine Methyl Ester Attenuate Carboplatin-Induced Ototoxicity in Dissociated Spiral Ganglion Neuron Cultures

OBJECTIVES: Carboplatin, a platinum-containing anti-cancer drug used to treat a variety of cancers, induces ototoxicity. Since, reactive oxygen species (ROS) and nitric oxide (NO) seem to be responsible for this toxicity, the antioxidant, N-acetyl-L-cysteine (L-NAC), and NO synthetase inhibitor, N-n...

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Detalles Bibliográficos
Autores principales: Moon, Il Joon, Kim, Ki Ryung, Chu, Ho-Suk, Kim, Se Hyung, Chung, Won-Ho, Cho, Yang-Sun, Hong, Sung Hwa
Formato: Texto
Lenguaje:English
Publicado: Korean Society of Otorhinolaryngology-Head and Neck Surgery 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062221/
https://www.ncbi.nlm.nih.gov/pubmed/21461057
http://dx.doi.org/10.3342/ceo.2011.4.1.11

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