SNP rs6457327 in the HLA region on chromosome 6p is predictive of the transformation of follicular lymphoma

Inherited risk determinants for follicular lymphoma (FL) have recently been described in the immune gene-rich human leukocyte antigen region on chromosome 6p. The known importance of host immune response to FL survival led us to evaluate these germline factors in FL outcome. We confirm the associati...

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Autores principales: Wrench, David, Leighton, Pamela, Skibola, Christine F., Conde, Lucia, Cazier, Jean-Baptiste, Matthews, Janet, Iqbal, Sameena, Carlotti, Emanuela, Bödör, Csaba, Montoto, Silvia, Calaminici, Maria, Gribben, John G., Lister, T. Andrew, Fitzgibbon, Jude
Formato: Texto
Lenguaje:English
Publicado: American Society of Hematology 2011
Materias:
Lymphoid Neoplasia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062316/
https://www.ncbi.nlm.nih.gov/pubmed/21233317
http://dx.doi.org/10.1182/blood-2010-10-315382
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author Wrench, David
Leighton, Pamela
Skibola, Christine F.
Conde, Lucia
Cazier, Jean-Baptiste
Matthews, Janet
Iqbal, Sameena
Carlotti, Emanuela
Bödör, Csaba
Montoto, Silvia
Calaminici, Maria
Gribben, John G.
Lister, T. Andrew
Fitzgibbon, Jude
author_facet Wrench, David
Leighton, Pamela
Skibola, Christine F.
Conde, Lucia
Cazier, Jean-Baptiste
Matthews, Janet
Iqbal, Sameena
Carlotti, Emanuela
Bödör, Csaba
Montoto, Silvia
Calaminici, Maria
Gribben, John G.
Lister, T. Andrew
Fitzgibbon, Jude
author_sort Wrench, David
collection PubMed
description Inherited risk determinants for follicular lymphoma (FL) have recently been described in the immune gene-rich human leukocyte antigen region on chromosome 6p. The known importance of host immune response to FL survival led us to evaluate these germline factors in FL outcome. We confirm the association of single nucleotide polymorphisms rs10484561 (P = 3.5 × 10(−9)) and rs6457327 (P = .008) with risk of FL and demonstrate that rs6457327 predicts both time to (P = .02) and risk of (P < .01) FL transformation independently of clinical variables, including the Follicular Lymphoma International Prognostic Index.
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spelling pubmed-30623162012-03-17 SNP rs6457327 in the HLA region on chromosome 6p is predictive of the transformation of follicular lymphoma Wrench, David Leighton, Pamela Skibola, Christine F. Conde, Lucia Cazier, Jean-Baptiste Matthews, Janet Iqbal, Sameena Carlotti, Emanuela Bödör, Csaba Montoto, Silvia Calaminici, Maria Gribben, John G. Lister, T. Andrew Fitzgibbon, Jude Blood Lymphoid Neoplasia Inherited risk determinants for follicular lymphoma (FL) have recently been described in the immune gene-rich human leukocyte antigen region on chromosome 6p. The known importance of host immune response to FL survival led us to evaluate these germline factors in FL outcome. We confirm the association of single nucleotide polymorphisms rs10484561 (P = 3.5 × 10(−9)) and rs6457327 (P = .008) with risk of FL and demonstrate that rs6457327 predicts both time to (P = .02) and risk of (P < .01) FL transformation independently of clinical variables, including the Follicular Lymphoma International Prognostic Index. American Society of Hematology 2011-03-17 /pmc/articles/PMC3062316/ /pubmed/21233317 http://dx.doi.org/10.1182/blood-2010-10-315382 Text en © 2011 by The American Society of Hematology https://creativecommons.org/licenses/by-nc/3.0/us/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/us/ (https://creativecommons.org/licenses/by-nc/3.0/us/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Lymphoid Neoplasia
Wrench, David
Leighton, Pamela
Skibola, Christine F.
Conde, Lucia
Cazier, Jean-Baptiste
Matthews, Janet
Iqbal, Sameena
Carlotti, Emanuela
Bödör, Csaba
Montoto, Silvia
Calaminici, Maria
Gribben, John G.
Lister, T. Andrew
Fitzgibbon, Jude
SNP rs6457327 in the HLA region on chromosome 6p is predictive of the transformation of follicular lymphoma
title SNP rs6457327 in the HLA region on chromosome 6p is predictive of the transformation of follicular lymphoma
title_full SNP rs6457327 in the HLA region on chromosome 6p is predictive of the transformation of follicular lymphoma
title_fullStr SNP rs6457327 in the HLA region on chromosome 6p is predictive of the transformation of follicular lymphoma
title_full_unstemmed SNP rs6457327 in the HLA region on chromosome 6p is predictive of the transformation of follicular lymphoma
title_short SNP rs6457327 in the HLA region on chromosome 6p is predictive of the transformation of follicular lymphoma
title_sort snp rs6457327 in the hla region on chromosome 6p is predictive of the transformation of follicular lymphoma
topic Lymphoid Neoplasia
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062316/
https://www.ncbi.nlm.nih.gov/pubmed/21233317
http://dx.doi.org/10.1182/blood-2010-10-315382
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