Activation of Src Mediates PDGF-Induced Smad1 Phosphorylation and Contributes to the Progression of Glomerulosclerosis in Glomerulonephritis

Platelet-derived growth factor (PDGF) plays critical roles in mesangial cell (MC) proliferation in mesangial proliferative glomerulonephritis. We showed previously that Smad1 contributes to PDGF-dependent proliferation of MCs, but the mechanism by which Smad1 is activated by PDGF is not precisely kn...

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Detalles Bibliográficos
Autores principales: Mima, Akira, Abe, Hideharu, Nagai, Kojiro, Arai, Hidenori, Matsubara, Takeshi, Araki, Makoto, Torikoshi, Kazuo, Tominaga, Tatsuya, Iehara, Noriyuki, Fukatsu, Atsushi, Kita, Toru, Doi, Toshio
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062564/
https://www.ncbi.nlm.nih.gov/pubmed/21445358
http://dx.doi.org/10.1371/journal.pone.0017929

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