Intermolecular masking of the HIV-1 Rev NLS by the cellular protein HIC: Novel insights into the regulation of Rev nuclear import

BACKGROUND: The HIV-1 regulatory protein Rev, which is essential for viral replication, mediates the nuclear export of unspliced viral transcripts. Rev nuclear function requires active nucleocytoplasmic shuttling, and Rev nuclear import is mediated by the recognition of its Nuclear Localisation Sign...

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Detalles Bibliográficos
Autores principales: Gu, Lili, Tsuji, Takahiro, Jarboui, Mohamed Ali, Yeo, Geok P, Sheehy, Noreen, Hall, William W, Gautier, Virginie W
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062594/
https://www.ncbi.nlm.nih.gov/pubmed/21401918
http://dx.doi.org/10.1186/1742-4690-8-17

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