IKKβ phosphorylation regulates RPS3 nuclear translocation and NF-κB function during Escherichia coli O157:H7 infection

NF-κB is a major gene regulator in immune responses and ribosomal protein S3 (RPS3) is an NF-κB subunit that directs specific gene transcription. However, it is unknown how RPS3 nuclear translocation is regulated. Here we report that IKKβ phosphorylation of serine 209 (S209) was crucial for RPS3 nuc...

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Detalles Bibliográficos
Autores principales: Wan, Fengyi, Weaver, Amanda, Gao, Xiaofei, Bern, Michael, Hardwidge, Philip R., Lenardo, Michael J.
Formato: Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062687/
https://www.ncbi.nlm.nih.gov/pubmed/21399639
http://dx.doi.org/10.1038/ni.2007

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