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The Animal Model of Spinal Cord Injury as an Experimental Pain Model

Pain, which remains largely unsolved, is one of the most crucial problems for spinal cord injury patients. Due to sensory problems, as well as motor dysfunctions, spinal cord injury research has proven to be complex and difficult. Furthermore, many types of pain are associated with spinal cord injur...

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Detalles Bibliográficos
Autores principales: Nakae, Aya, Nakai, Kunihiro, Yano, Kenji, Hosokawa, Ko, Shibata, Masahiko, Mashimo, Takashi
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062973/
https://www.ncbi.nlm.nih.gov/pubmed/21436995
http://dx.doi.org/10.1155/2011/939023
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author Nakae, Aya
Nakai, Kunihiro
Yano, Kenji
Hosokawa, Ko
Shibata, Masahiko
Mashimo, Takashi
author_facet Nakae, Aya
Nakai, Kunihiro
Yano, Kenji
Hosokawa, Ko
Shibata, Masahiko
Mashimo, Takashi
author_sort Nakae, Aya
collection PubMed
description Pain, which remains largely unsolved, is one of the most crucial problems for spinal cord injury patients. Due to sensory problems, as well as motor dysfunctions, spinal cord injury research has proven to be complex and difficult. Furthermore, many types of pain are associated with spinal cord injury, such as neuropathic, visceral, and musculoskeletal pain. Many animal models of spinal cord injury exist to emulate clinical situations, which could help to determine common mechanisms of pathology. However, results can be easily misunderstood and falsely interpreted. Therefore, it is important to fully understand the symptoms of human spinal cord injury, as well as the various spinal cord injury models and the possible pathologies. The present paper summarizes results from animal models of spinal cord injury, as well as the most effective use of these models.
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spelling pubmed-30629732011-03-24 The Animal Model of Spinal Cord Injury as an Experimental Pain Model Nakae, Aya Nakai, Kunihiro Yano, Kenji Hosokawa, Ko Shibata, Masahiko Mashimo, Takashi J Biomed Biotechnol Review Article Pain, which remains largely unsolved, is one of the most crucial problems for spinal cord injury patients. Due to sensory problems, as well as motor dysfunctions, spinal cord injury research has proven to be complex and difficult. Furthermore, many types of pain are associated with spinal cord injury, such as neuropathic, visceral, and musculoskeletal pain. Many animal models of spinal cord injury exist to emulate clinical situations, which could help to determine common mechanisms of pathology. However, results can be easily misunderstood and falsely interpreted. Therefore, it is important to fully understand the symptoms of human spinal cord injury, as well as the various spinal cord injury models and the possible pathologies. The present paper summarizes results from animal models of spinal cord injury, as well as the most effective use of these models. Hindawi Publishing Corporation 2011 2011-03-07 /pmc/articles/PMC3062973/ /pubmed/21436995 http://dx.doi.org/10.1155/2011/939023 Text en Copyright © 2011 Aya Nakae et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Nakae, Aya
Nakai, Kunihiro
Yano, Kenji
Hosokawa, Ko
Shibata, Masahiko
Mashimo, Takashi
The Animal Model of Spinal Cord Injury as an Experimental Pain Model
title The Animal Model of Spinal Cord Injury as an Experimental Pain Model
title_full The Animal Model of Spinal Cord Injury as an Experimental Pain Model
title_fullStr The Animal Model of Spinal Cord Injury as an Experimental Pain Model
title_full_unstemmed The Animal Model of Spinal Cord Injury as an Experimental Pain Model
title_short The Animal Model of Spinal Cord Injury as an Experimental Pain Model
title_sort animal model of spinal cord injury as an experimental pain model
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062973/
https://www.ncbi.nlm.nih.gov/pubmed/21436995
http://dx.doi.org/10.1155/2011/939023
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