Phosphatidylserine is a critical modulator for Akt activation

Akt activation relies on the binding of Akt to phosphatidylinositol-3,4,5-trisphosphate (PIP(3)) in the membrane. Here, we demonstrate that Akt activation requires not only PIP(3) but also membrane phosphatidylserine (PS). The extent of insulin-like growth factor–induced Akt activation and downstrea...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Bill X., Akbar, Mohammed, Kevala, Karl, Kim, Hee-Yong
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063130/
https://www.ncbi.nlm.nih.gov/pubmed/21402788
http://dx.doi.org/10.1083/jcb.201005100

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063130/
https://www.ncbi.nlm.nih.gov/pubmed/21402788
http://dx.doi.org/10.1083/jcb.201005100

Ejemplares similares