Cargando…

Expression of DDX3 Is Directly Modulated by Hypoxia Inducible Factor-1 Alpha in Breast Epithelial Cells

DEAD box protein, DDX3, is aberrantly expressed in breast cancer cells ranging from weakly invasive to aggressive phenotypes and functions as an important regulator of cancer cell growth and survival. Here, we demonstrate that hypoxia inducible factor-1α is a transcriptional activator of DDX3 in bre...

Descripción completa

Detalles Bibliográficos
Autores principales:	Botlagunta, Mahendran, Krishnamachary, Balaji, Vesuna, Farhad, Winnard, Paul T., Bol, Guus M., Patel, Arvind H., Raman, Venu
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063174/ https://www.ncbi.nlm.nih.gov/pubmed/21448281 http://dx.doi.org/10.1371/journal.pone.0017563

Ejemplares similares

NZ51, a ring-expanded nucleoside analog, inhibits motility and viability of breast cancer cells by targeting the RNA helicase DDX3
por: Xie, Min, et al.
Publicado: (2015)

Targeting RNA helicase DDX3 in stem cell maintenance and teratoma formation
por: Kerr, Candace L., et al.
Publicado: (2019)

Neoplastic transformation of breast epithelial cells by genotoxic stress
por: Botlagunta, Mahendran, et al.
Publicado: (2010)

Role of DDX3 in the pathogenesis of inflammatory bowel disease
por: Tantravedi, Saritha, et al.
Publicado: (2017)

Nuclear DDX3 expression predicts poor outcome in colorectal and breast cancer
por: Heerma van Voss, Marise R, et al.
Publicado: (2017)

Expression of the RNA Helicase DDX3 and the Hypoxia Response in Breast Cancer
por: Bol, Guus M., et al.
Publicado: (2013)

DDX3, a potential target for cancer treatment
por: Bol, Guus Martinus, et al.
Publicado: (2015)

Targeting DDX3 in Medulloblastoma Using the Small Molecule Inhibitor RK-33
por: Tantravedi, Saritha, et al.
Publicado: (2018)

Divergent organ-specific isogenic metastatic cell lines identified using multi-omics exhibit differential drug sensitivity
por: Winnard, Paul T., et al.
Publicado: (2020)

RK-33, a small molecule inhibitor of host RNA helicase DDX3, suppresses multiple variants of SARS-CoV-2
por: Vesuna, Farhad, et al.
Publicado: (2022)

Genomic pathways modulated by Twist in breast cancer
por: Vesuna, Farhad, et al.
Publicado: (2017)

Targeting mitochondrial translation by inhibiting DDX3: a novel radiosensitization strategy for cancer treatment
por: Heerma van Voss, Marise R., et al.
Publicado: (2017)

Organ-specific isogenic metastatic breast cancer cell lines exhibit distinct Raman spectral signatures and metabolomes
por: Winnard, Paul T., et al.
Publicado: (2017)

Ketorolac salt is a newly discovered DDX3 inhibitor to treat oral cancer
por: Samal, Sabindra K., et al.
Publicado: (2015)

Targeting DDX3 with a small molecule inhibitor for lung cancer therapy
por: Bol, Guus M, et al.
Publicado: (2015)

Identification of the DEAD box RNA helicase DDX3 as a therapeutic target in colorectal cancer
por: van Voss, Marise R. Heerma, et al.
Publicado: (2015)

Global Effects of DDX3 Inhibition on Cell Cycle Regulation Identified by a Combined Phosphoproteomics and Single Cell Tracking Approach
por: Heerma van Voss, Marise R., et al.
Publicado: (2018)

In vitro anti-cancer activity of doxorubicin against human RNA helicase, DDX3
por: Botlagunta, Mahendran, et al.
Publicado: (2016)

Functional roles of FAP-α in metabolism, migration and invasion of human cancer cells
por: Mori, Noriko, et al.
Publicado: (2023)

Hypoxia Regulates CD44 and Its Variant Isoforms through HIF-1α in Triple Negative Breast Cancer
por: Krishnamachary, Balaji, et al.
Publicado: (2012)

Twist contributes to hormone resistance in breast cancer by down-regulating estrogen receptor alpha
por: Vesuna, Farhad, et al.
Publicado: (2011)

miRNA expression patterns in normal breast tissue and invasive breast cancers of BRCA1 and BRCA2 germ-line mutation carriers
por: Vos, Shoko, et al.
Publicado: (2015)

Venezuelan equine encephalitis virus non-structural protein 3 (nsP3) interacts with RNA helicases DDX1 and DDX3 in infected cells
por: Amaya, Moushimi, et al.
Publicado: (2016)

Cytoplasmic DDX3 as prognosticator in male breast cancer
por: van der Pol, Carmen C., et al.
Publicado: (2021)

In-Vitro and in-Silico characterization of Sophora interrupta plant extract as an anticancer activity
por: Mathi, Pardhasaradhi, et al.
Publicado: (2014)

Morphological and Chemoprofile (Liquid Chromatography-mass Spectroscopy and Gas Chromatography-mass Spectroscopy) Comparisons of Cyperus scariosus R. Br and Cyperus rotundus L.
por: Kakarla, Lavanya, et al.
Publicado: (2015)

Isogenic Cell Lines Derived from Specific Organ Metastases Exhibit Divergent Cytogenomic Aberrations
por: Winnard, Paul T., et al.
Publicado: (2023)

The prognostic effect of DDX3 upregulation in distant breast cancer metastases
por: Heerma van Voss, Marise R., et al.
Publicado: (2016)

Hypoxia Patterns in Primary and Metastatic Prostate Cancer Environments()
por: Bharti, Santosh Kumar, et al.
Publicado: (2019)

Combining Optical Reporter Proteins with Different Half-lives to Detect Temporal Evolution of Hypoxia and Reoxygenation in Tumors
por: Danhier, Pierre, et al.
Publicado: (2015)

Classification and diagnostic prediction of breast cancer metastasis on clinical data using machine learning algorithms
por: Botlagunta, Mahendran, et al.
Publicado: (2023)

HIF and COX-2 expression in triple negative breast cancer cells with hypoxia and 5-fluorouracil
por: Mori, Noriko, et al.
Publicado: (2020)

Hypoxia Inducible Factors Modify Collagen I Fibers in MDA-MB-231 Triple Negative Breast Cancer Xenografts()()
por: Goggins, Eibhlin, et al.
Publicado: (2017)

Isolation and Characterization of the Anticancer Compound Piceatannol from Sophora Interrupta Bedd
por: Mathi, Pardhasaradhi, et al.
Publicado: (2015)

Identification of human cyclooxegenase-2 inhibitors from Cyperus scariosus (R.Br) rhizomes
por: Kakarla, Lavanya, et al.
Publicado: (2014)

Collagen fibers mediate MRI-detected water diffusion and anisotropy in breast cancers
por: Kakkad, Samata, et al.
Publicado: (2016)

DDX3X and DDX3Y are redundant in protein synthesis
por: Venkataramanan, Srivats, et al.
Publicado: (2021)

RNA Helicase DDX3 Regulates RAD51 Localization and DNA Damage Repair in Ewing Sarcoma
por: Randolph, Matthew E., et al.
Publicado: (2023)

Human DDX3 functions in translation and interacts with the translation initiation factor eIF3
por: Lee, Chung-Sheng, et al.
Publicado: (2008)

Vorinostat suppresses hypoxia signaling by modulating nuclear translocation of hypoxia inducible factor 1 alpha
por: Zhang, Chao, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_rb3qrct0gfkder5mi6on68r6rm