Rational Design of T Cell Receptors with Enhanced Sensitivity for Antigen

Enhancing the affinity of therapeutic T cell receptors (TCR) without altering their specificity is a significant challenge for adoptive immunotherapy. Current efforts have primarily relied on empirical approaches. Here, we used structural analyses to identify a glycine-serine variation in the TCR th...

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Detalles Bibliográficos
Autores principales: Alli, Rajshekhar, Zhang, Ziwei M., Nguyen, Phuong, Zheng, Jie J., Geiger, Terrence L.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063236/
https://www.ncbi.nlm.nih.gov/pubmed/21455495
http://dx.doi.org/10.1371/journal.pone.0018027

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