Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1

Loss of Omi/HtrA2 function leads to nerve cell loss in mouse models and has been linked to neurodegeneration in Parkinson's and Huntington's disease. Omi/HtrA2 is a serine protease released as a pro-apoptotic factor from the mitochondrial intermembrane space into the cytosol. Under physiol...

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Detalles Bibliográficos
Autores principales: Kieper, Nicole, Holmström, Kira M., Ciceri, Dalila, Fiesel, Fabienne C., Wolburg, Hartwig, Ziviani, Elena, Whitworth, Alexander J., Martins, L. Miguel, Kahle, Philipp J., Krüger, Rejko
Formato: Texto
Lenguaje:English
Publicado: Academic Press 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063334/
https://www.ncbi.nlm.nih.gov/pubmed/20064504
http://dx.doi.org/10.1016/j.yexcr.2010.01.005

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