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Telmisartan improves nonalcoholic steatohepatitis in medaka (Oryzias latipes) by reducing macrophage infiltration and fat accumulation
We investigated the efficacy of the antihypertensive drug telmisartan (Tel) and the mechanisms underlying the progression from simple steatosis to nonalcoholic steatohepatitis (NASH) in a medaka (Oryzias latipes) NASH model. We used the NASH activity score (NAS) developed in humans to assess the his...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Springer-Verlag
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063342/ https://www.ncbi.nlm.nih.gov/pubmed/21327395 http://dx.doi.org/10.1007/s00441-011-1132-7 |
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author | Kuwashiro, Shinya Terai, Shuji Oishi, Toshiyuki Fujisawa, Koichi Matsumoto, Toshihiko Nishina, Hiroshi Sakaida, Isao |
author_facet | Kuwashiro, Shinya Terai, Shuji Oishi, Toshiyuki Fujisawa, Koichi Matsumoto, Toshihiko Nishina, Hiroshi Sakaida, Isao |
author_sort | Kuwashiro, Shinya |
collection | PubMed |
description | We investigated the efficacy of the antihypertensive drug telmisartan (Tel) and the mechanisms underlying the progression from simple steatosis to nonalcoholic steatohepatitis (NASH) in a medaka (Oryzias latipes) NASH model. We used the NASH activity score (NAS) developed in humans to assess the histology of the medaka NASH model and found that NAS increased with time. Further, TUNEL-positive apoptosis hepatocytes were found in the medaka NASH model. Tel administration resulted in the increased expression of liver peroxisome proliferator-activated receptor-γ, carnitine palmitoyltransferase 1 and acyl-CoA oxidase 1 and decreased the number of 8-hydroxydeoxyguanosine-positive hepatocytes and the migration of macrophages positive for diastase-periodic-acid-Schiff. Medaka NAS was improved by Tel administration but fatty acid content was not affected. Tel reduced the infiltration of macrophages into the liver and ameliorated NASH pathology. |
format | Text |
id | pubmed-3063342 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Springer-Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-30633422011-04-05 Telmisartan improves nonalcoholic steatohepatitis in medaka (Oryzias latipes) by reducing macrophage infiltration and fat accumulation Kuwashiro, Shinya Terai, Shuji Oishi, Toshiyuki Fujisawa, Koichi Matsumoto, Toshihiko Nishina, Hiroshi Sakaida, Isao Cell Tissue Res Regular Article We investigated the efficacy of the antihypertensive drug telmisartan (Tel) and the mechanisms underlying the progression from simple steatosis to nonalcoholic steatohepatitis (NASH) in a medaka (Oryzias latipes) NASH model. We used the NASH activity score (NAS) developed in humans to assess the histology of the medaka NASH model and found that NAS increased with time. Further, TUNEL-positive apoptosis hepatocytes were found in the medaka NASH model. Tel administration resulted in the increased expression of liver peroxisome proliferator-activated receptor-γ, carnitine palmitoyltransferase 1 and acyl-CoA oxidase 1 and decreased the number of 8-hydroxydeoxyguanosine-positive hepatocytes and the migration of macrophages positive for diastase-periodic-acid-Schiff. Medaka NAS was improved by Tel administration but fatty acid content was not affected. Tel reduced the infiltration of macrophages into the liver and ameliorated NASH pathology. Springer-Verlag 2011-02-16 2011 /pmc/articles/PMC3063342/ /pubmed/21327395 http://dx.doi.org/10.1007/s00441-011-1132-7 Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
spellingShingle | Regular Article Kuwashiro, Shinya Terai, Shuji Oishi, Toshiyuki Fujisawa, Koichi Matsumoto, Toshihiko Nishina, Hiroshi Sakaida, Isao Telmisartan improves nonalcoholic steatohepatitis in medaka (Oryzias latipes) by reducing macrophage infiltration and fat accumulation |
title | Telmisartan improves nonalcoholic steatohepatitis in medaka (Oryzias latipes) by reducing macrophage infiltration and fat accumulation |
title_full | Telmisartan improves nonalcoholic steatohepatitis in medaka (Oryzias latipes) by reducing macrophage infiltration and fat accumulation |
title_fullStr | Telmisartan improves nonalcoholic steatohepatitis in medaka (Oryzias latipes) by reducing macrophage infiltration and fat accumulation |
title_full_unstemmed | Telmisartan improves nonalcoholic steatohepatitis in medaka (Oryzias latipes) by reducing macrophage infiltration and fat accumulation |
title_short | Telmisartan improves nonalcoholic steatohepatitis in medaka (Oryzias latipes) by reducing macrophage infiltration and fat accumulation |
title_sort | telmisartan improves nonalcoholic steatohepatitis in medaka (oryzias latipes) by reducing macrophage infiltration and fat accumulation |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063342/ https://www.ncbi.nlm.nih.gov/pubmed/21327395 http://dx.doi.org/10.1007/s00441-011-1132-7 |
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