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Prevalence of adverse drug reactions at a private tertiary care hospital in south India

BACKGROUND: Adverse Drug Reactions (ADRs) constitute an enormous burden for the society. The aim of the present study was to detect, document, assess and report the suspected ADRs and preparation of guidelines to minimize the incidence of ADRs. METHODS: A prospective-observational study was conducte...

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Autores principales: Sriram, Shanmugam, Ghasemi, Ali, Ramasamy, Rajeswari, Devi, Manjula, Balasubramanian, Rajalingam, Ravi, Thengungal Kochupapy, Sabzghabaee, Ali Mohammad
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063432/
https://www.ncbi.nlm.nih.gov/pubmed/21448378
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author Sriram, Shanmugam
Ghasemi, Ali
Ramasamy, Rajeswari
Devi, Manjula
Balasubramanian, Rajalingam
Ravi, Thengungal Kochupapy
Sabzghabaee, Ali Mohammad
author_facet Sriram, Shanmugam
Ghasemi, Ali
Ramasamy, Rajeswari
Devi, Manjula
Balasubramanian, Rajalingam
Ravi, Thengungal Kochupapy
Sabzghabaee, Ali Mohammad
author_sort Sriram, Shanmugam
collection PubMed
description BACKGROUND: Adverse Drug Reactions (ADRs) constitute an enormous burden for the society. The aim of the present study was to detect, document, assess and report the suspected ADRs and preparation of guidelines to minimize the incidence of ADRs. METHODS: A prospective-observational study was conducted in the Department of General Medicine of a tertiary care hospital for 12 months from April 2008 to March 2009. Detected and suspected ADRs were analyzed for causality, severity and preventability using appropriate validated scales and were reported. ADR alert card was prepared and given to patients. Therapeutic guidelines were prepared and given to the relevant departments. RESULTS: A total of 57 ADRs were detected, documented, assessed and reported during the study period the incidence was found to be 1.8%. Assessment of severity of the suspected ADRs revealed that 12% of suspected ADRs were severe and 49% of ADRs were moderate in severity. Causality assessment was done which revealed 63% of ADRs were possibly drug-related. The majority of patients who had suffered from ADRs were above 60 years (56%). Gastrointestinal system was most commonly affected (37%) and the drug class mostly associated with ADRs was antibiotics (23%). Preventability of ADRs was assessed; and the results revealed that 28% of ADRs were definitely preventable. CONCLUSIONS: Measures to improve detection and reporting of adverse drug reactions by all health care professionals is recommended to be undertaken, to ensure, and improve patient's safety. In this way, hospital/clinical pharmacists play the cornerstone role.
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spelling pubmed-30634322011-03-28 Prevalence of adverse drug reactions at a private tertiary care hospital in south India Sriram, Shanmugam Ghasemi, Ali Ramasamy, Rajeswari Devi, Manjula Balasubramanian, Rajalingam Ravi, Thengungal Kochupapy Sabzghabaee, Ali Mohammad J Res Med Sci Original Article BACKGROUND: Adverse Drug Reactions (ADRs) constitute an enormous burden for the society. The aim of the present study was to detect, document, assess and report the suspected ADRs and preparation of guidelines to minimize the incidence of ADRs. METHODS: A prospective-observational study was conducted in the Department of General Medicine of a tertiary care hospital for 12 months from April 2008 to March 2009. Detected and suspected ADRs were analyzed for causality, severity and preventability using appropriate validated scales and were reported. ADR alert card was prepared and given to patients. Therapeutic guidelines were prepared and given to the relevant departments. RESULTS: A total of 57 ADRs were detected, documented, assessed and reported during the study period the incidence was found to be 1.8%. Assessment of severity of the suspected ADRs revealed that 12% of suspected ADRs were severe and 49% of ADRs were moderate in severity. Causality assessment was done which revealed 63% of ADRs were possibly drug-related. The majority of patients who had suffered from ADRs were above 60 years (56%). Gastrointestinal system was most commonly affected (37%) and the drug class mostly associated with ADRs was antibiotics (23%). Preventability of ADRs was assessed; and the results revealed that 28% of ADRs were definitely preventable. CONCLUSIONS: Measures to improve detection and reporting of adverse drug reactions by all health care professionals is recommended to be undertaken, to ensure, and improve patient's safety. In this way, hospital/clinical pharmacists play the cornerstone role. Medknow Publications & Media Pvt Ltd 2011-01 /pmc/articles/PMC3063432/ /pubmed/21448378 Text en Copyright: © Journal of Research in Medical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Sriram, Shanmugam
Ghasemi, Ali
Ramasamy, Rajeswari
Devi, Manjula
Balasubramanian, Rajalingam
Ravi, Thengungal Kochupapy
Sabzghabaee, Ali Mohammad
Prevalence of adverse drug reactions at a private tertiary care hospital in south India
title Prevalence of adverse drug reactions at a private tertiary care hospital in south India
title_full Prevalence of adverse drug reactions at a private tertiary care hospital in south India
title_fullStr Prevalence of adverse drug reactions at a private tertiary care hospital in south India
title_full_unstemmed Prevalence of adverse drug reactions at a private tertiary care hospital in south India
title_short Prevalence of adverse drug reactions at a private tertiary care hospital in south India
title_sort prevalence of adverse drug reactions at a private tertiary care hospital in south india
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063432/
https://www.ncbi.nlm.nih.gov/pubmed/21448378
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