Ultra-Deep Sequencing of Mouse Mitochondrial DNA: Mutational Patterns and Their Origins

Somatic mutations of mtDNA are implicated in the aging process, but there is no universally accepted method for their accurate quantification. We have used ultra-deep sequencing to study genome-wide mtDNA mutation load in the liver of normally- and prematurely-aging mice. Mice that are homozygous fo...

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Detalles Bibliográficos
Autores principales: Ameur, Adam, Stewart, James B., Freyer, Christoph, Hagström, Erik, Ingman, Max, Larsson, Nils-Göran, Gyllensten, Ulf
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063763/
https://www.ncbi.nlm.nih.gov/pubmed/21455489
http://dx.doi.org/10.1371/journal.pgen.1002028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063763/
https://www.ncbi.nlm.nih.gov/pubmed/21455489
http://dx.doi.org/10.1371/journal.pgen.1002028

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