Assessing the In Vitro Fitness of an Oseltamivir-Resistant Seasonal A/H1N1 Influenza Strain Using a Mathematical Model

In 2007, the A/Brisbane/59/2007 (H1N1) seasonal influenza virus strain acquired the oseltamivir-resistance mutation H275Y in its neuraminidase (NA) gene. Although previous studies had demonstrated that this mutation impaired the replication capacity of the influenza virus in vitro and in vivo, the A...

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Detalles Bibliográficos
Autores principales: Holder, Benjamin P., Simon, Philippe, Liao, Laura E., Abed, Yacine, Bouhy, Xavier, Beauchemin, Catherine A. A., Boivin, Guy
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063785/
https://www.ncbi.nlm.nih.gov/pubmed/21455300
http://dx.doi.org/10.1371/journal.pone.0014767

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