Cargando…

Systematic Evaluation of the Descriptive and Predictive Performance of Paediatric Morphine Population Models

PURPOSE: A framework for the evaluation of paediatric population models is proposed and applied to two different paediatric population pharmacokinetic models for morphine. One covariate model was based on a systematic covariate analysis, the other on fixed allometric scaling principles. METHODS: The...

Descripción completa

Detalles Bibliográficos
Autores principales:	Krekels, Elke H. J., van Hasselt, Johan G. C., Tibboel, Dick, Danhof, Meindert, Knibbe, Catherijne A. J.
Formato:	Texto
Lenguaje:	English
Publicado:	Springer US 2010
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063866/ https://www.ncbi.nlm.nih.gov/pubmed/21153913 http://dx.doi.org/10.1007/s11095-010-0333-1

Ejemplares similares

Allometric Scaling of Clearance in Paediatric Patients: When Does the Magic of 0.75 Fade?
por: Calvier, Elisa A. M., et al.
Publicado: (2016)

The role of population PK–PD modelling in paediatric clinical research
por: De Cock, Roosmarijn F. W., et al.
Publicado: (2010)

Developmental changes rather than repeated administration drive paracetamol glucuronidation in neonates and infants
por: Krekels, Elke H. J., et al.
Publicado: (2015)

A Bodyweight-Dependent Allometric Exponent for Scaling Clearance Across the Human Life-Span
por: Wang, Chenguang, et al.
Publicado: (2012)

Quantifying the Pharmacodynamics of Morphine in the Treatment of Postoperative Pain in Preverbal Children
por: Goulooze, Sebastiaan C., et al.
Publicado: (2021)

Can Population Modelling Principles be Used to Identify Key PBPK Parameters for Paediatric Clearance Predictions? An Innovative Application of Optimal Design Theory
por: Calvier, Elisa A. M., et al.
Publicado: (2018)

Exploring the Relationship Between Morphine Concentration and Oversedation in Children After Cardiac Surgery
por: Valkenburg, Abraham J., et al.
Publicado: (2020)

Population pharmacokinetic-pharmacodynamic model of propofol in adolescents undergoing scoliosis surgery with intraoperative wake-up test: a study using Bispectral index and composite auditory evoked potentials as pharmacodynamic endpoints
por: Blussé van Oud-Alblas, Heleen J., et al.
Publicado: (2019)

Drugs Being Eliminated via the Same Pathway Will Not Always Require Similar Pediatric Dose Adjustments
por: Calvier, Elisa A. M., et al.
Publicado: (2018)

From Pediatric Covariate Model to Semiphysiological Function for Maturation: Part I–Extrapolation of a Covariate Model From Morphine to Zidovudine
por: Krekels, E H J, et al.
Publicado: (2012)

Towards Evidence-Based Weaning: a Mechanism-Based Pharmacometric Model to Characterize Iatrogenic Withdrawal Syndrome in Critically Ill Children
por: Goulooze, Sebastiaan C., et al.
Publicado: (2021)

Supervised Multidimensional Item Response Theory Modeling of Pediatric Iatrogenic Withdrawal Symptoms
por: Goulooze, Sebastiaan C., et al.
Publicado: (2019)

Morphine Pharmacodynamics in Mechanically Ventilated Preterm Neonates Undergoing Endotracheal Suctioning
por: Välitalo, PA, et al.
Publicado: (2017)

A Pediatric Covariate Function for CYP3A-Mediated Midazolam Clearance Can Scale Clearance of Selected CYP3A Substrates in Children
por: Brussee, Janneke M., et al.
Publicado: (2019)

The Predictive Value of Glomerular Filtration Rate-Based Scaling of Pediatric Clearance and Doses for Drugs Eliminated by Glomerular Filtration with Varying Protein-Binding Properties
por: Cristea, Sinziana, et al.
Publicado: (2020)

Maturation of Paracetamol Elimination Routes in Preterm Neonates Born Below 32 Weeks of Gestation
por: Wu, Yunjiao, et al.
Publicado: (2023)

Vancomycin Clearance in Obese Adults is not Predictive of Clearance in Obese Adolescents
por: Zhang, Tan, et al.
Publicado: (2023)

Scaling Drug Clearance from Adults to the Young Children for Drugs Undergoing Hepatic Metabolism: A Simulation Study to Search for the Simplest Scaling Method
por: Calvier, E. A. M., et al.
Publicado: (2019)

From Pediatric Covariate Model to Semiphysiological Function for Maturation: Part II—Sensitivity to Physiological and Physicochemical Properties
por: Krekels, E H J, et al.
Publicado: (2012)

Influence of Morbid Obesity on the Pharmacokinetics of Morphine, Morphine-3-Glucuronide, and Morphine-6-Glucuronide
por: de Hoogd, Sjoerd, et al.
Publicado: (2017)

Development of Human Membrane Transporters: Drug Disposition and Pharmacogenetics
por: Mooij, Miriam G., et al.
Publicado: (2015)

The Influence of Normalization Weight in Population Pharmacokinetic Covariate Models
por: Goulooze, Sebastiaan C., et al.
Publicado: (2018)

The Influence of Drug Properties and Ontogeny of Transporters on Pediatric Renal Clearance through Glomerular Filtration and Active Secretion: a Simulation-Based Study
por: Cristea, Sînziana, et al.
Publicado: (2020)

Children Are Not Small Adults, but Can We Treat Them As Such?
por: Krekels, Elke H.J., et al.
Publicado: (2019)

Estimation of Ontogeny Functions for Renal Transporters Using a Combined Population Pharmacokinetic and Physiology-Based Pharmacokinetic Approach: Application to OAT1,3
por: Cristea, Sînziana, et al.
Publicado: (2021)

Pharmacokinetics and Pharmacodynamics of Posaconazole
por: Chen, Lu, et al.
Publicado: (2020)

Predicting CYP3A‐mediated midazolam metabolism in critically ill neonates, infants, children and adults with inflammation and organ failure
por: Brussee, Janneke M., et al.
Publicado: (2017)

Midazolam Infusion and Disease Severity Affect the Level of Sedation in Children: A Parametric Time-to-Event Analysis
por: Upadhyay, Parth J., et al.
Publicado: (2021)

Remifentanil versus fentanyl during cardiac surgery on the incidence of chronic thoracic pain (REFLECT): study protocol for a randomized controlled trial
por: de Hoogd, Sjoerd, et al.
Publicado: (2014)

Dose‐linearity of the pharmacokinetics of an intravenous [(14)C]midazolam microdose in children
por: van Groen, Bianca D., et al.
Publicado: (2019)

Characterization of Intestinal and Hepatic CYP3A-Mediated Metabolism of Midazolam in Children Using a Physiological Population Pharmacokinetic Modelling Approach
por: Brussee, Janneke M., et al.
Publicado: (2018)

First dose in children: physiological insights into pharmacokinetic scaling approaches and their implications in paediatric drug development
por: Strougo, Ashley, et al.
Publicado: (2012)

Pharmacokinetics of Morphine, Morphine-3-Glucuronide and Morphine-6-Glucuronide in Terminally Ill Adult Patients
por: Franken, Linda G., et al.
Publicado: (2015)

Kinetics of drug action in disease states: towards physiology-based pharmacodynamic (PBPD) models
por: Danhof, Meindert
Publicado: (2015)

Population Pharmacokinetic Modeling of Acetaminophen and Metabolites in Children After Cardiac Surgery With Cardiopulmonary Bypass
por: Mian, P., et al.
Publicado: (2019)

Integration of pharmacometabolomics with pharmacokinetics and pharmacodynamics: towards personalized drug therapy
por: Kantae, Vasudev, et al.
Publicado: (2016)

The Oral Bioavailability and Metabolism of Midazolam in Stable Critically Ill Children: A Pharmacokinetic Microtracing Study
por: van Groen, Bianca D., et al.
Publicado: (2020)

Extensions to the Visual Predictive Check to facilitate model performance evaluation
por: Post, Teun M., et al.
Publicado: (2008)

Short- and long-term impact of remifentanil on thermal detection and pain thresholds after cardiac surgery: A randomised controlled trial
por: de Hoogd, Sjoerd, et al.
Publicado: (2019)

Modelling the delay between pharmacokinetics and EEG effects of morphine in rats: binding kinetic versus effect compartment models
por: de Witte, Wilhelmus E. A., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_lg290v2qdasld3q9qfp57mbclq