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Over-expression of Grhl2 causes spina bifida in the Axial defects mutant mouse

Cranial neural tube defects (NTDs) occur in mice carrying mutant alleles of many different genes, whereas isolated spinal NTDs (spina bifida) occur in fewer models, despite being common human birth defects. Spina bifida occurs at high frequency in the Axial defects (Axd) mouse mutant but the causati...

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Detalles Bibliográficos
Autores principales: Brouns, Madeleine R., De Castro, Sandra C.P., Terwindt-Rouwenhorst, Els A., Massa, Valentina, Hekking, Johan W., Hirst, Caroline S., Savery, Dawn, Munts, Chantal, Partridge, Darren, Lamers, Wout, Köhler, Eleonore, van Straaten, Henny W., Copp, Andrew J., Greene, Nicholas D.E.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063985/
https://www.ncbi.nlm.nih.gov/pubmed/21262862
http://dx.doi.org/10.1093/hmg/ddr031