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Pulse Pressure Predicts Incident Cardiovascular Disease but Not Diabetic Nephropathy in Patients With Type 1 Diabetes (The FinnDiane Study)

OBJECTIVE: Pulse pressure (PP), an estimate of arterial stiffness, has been shown to be associated with incident cardiovascular disease (CVD) in patients with type 1 diabetes (T1D). However, diabetic kidney disease, a strong predictor of CVD, was not previously taken into account. Furthermore, the r...

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Autores principales: Gordin, Daniel, Wadén, Johan, Forsblom, Carol, Thorn, Lena, Rosengård-Bärlund, Milla, Tolonen, Nina, Saraheimo, Markku, Harjutsalo, Valma, Groop, Per-Henrik
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064046/
https://www.ncbi.nlm.nih.gov/pubmed/21330642
http://dx.doi.org/10.2337/dc10-2013
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author Gordin, Daniel
Wadén, Johan
Forsblom, Carol
Thorn, Lena
Rosengård-Bärlund, Milla
Tolonen, Nina
Saraheimo, Markku
Harjutsalo, Valma
Groop, Per-Henrik
author_facet Gordin, Daniel
Wadén, Johan
Forsblom, Carol
Thorn, Lena
Rosengård-Bärlund, Milla
Tolonen, Nina
Saraheimo, Markku
Harjutsalo, Valma
Groop, Per-Henrik
author_sort Gordin, Daniel
collection PubMed
description OBJECTIVE: Pulse pressure (PP), an estimate of arterial stiffness, has been shown to be associated with incident cardiovascular disease (CVD) in patients with type 1 diabetes (T1D). However, diabetic kidney disease, a strong predictor of CVD, was not previously taken into account. Furthermore, the role of PP as a predictor of diabetic nephropathy is not known. Therefore, we prospectively investigated the associations between PP and these diabetes complications in patients with T1D. RESEARCH DESIGN AND METHODS: A total of 4,509 patients from the FinnDiane Study participated. Follow-up data on incident CVD events and renal status (median 5.3 years) were available in 69 and 76% of the patients, respectively. Altogether, 269 patients (8.6%) had an incident CVD event and 370 patients (10.8%) progressed to a higher level of albuminuria or to end-stage renal disease. RESULTS: PP was higher at baseline in patients who experienced a CVD event (66 ± 18 vs. 52 ± 14 mmHg; P < 0.001) or progressed in their renal status (58 ± 18 vs. 54 ± 15 mmHg; P < 0.01) during follow-up. In a Cox regression model, PP was independently associated with a first ever CVD event (hazard ratio per 10 mmHg 1.22 [95% CI 1.10–1.34]) but not progression of renal disease (1.00 [0.89–1.12]) after adjustments for traditional risk factors. CONCLUSIONS: PP, a marker of arterial stiffness, is a risk factor for cardiovascular complications but not for diabetic nephropathy in patients with T1D.
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spelling pubmed-30640462012-04-01 Pulse Pressure Predicts Incident Cardiovascular Disease but Not Diabetic Nephropathy in Patients With Type 1 Diabetes (The FinnDiane Study) Gordin, Daniel Wadén, Johan Forsblom, Carol Thorn, Lena Rosengård-Bärlund, Milla Tolonen, Nina Saraheimo, Markku Harjutsalo, Valma Groop, Per-Henrik Diabetes Care Original Research OBJECTIVE: Pulse pressure (PP), an estimate of arterial stiffness, has been shown to be associated with incident cardiovascular disease (CVD) in patients with type 1 diabetes (T1D). However, diabetic kidney disease, a strong predictor of CVD, was not previously taken into account. Furthermore, the role of PP as a predictor of diabetic nephropathy is not known. Therefore, we prospectively investigated the associations between PP and these diabetes complications in patients with T1D. RESEARCH DESIGN AND METHODS: A total of 4,509 patients from the FinnDiane Study participated. Follow-up data on incident CVD events and renal status (median 5.3 years) were available in 69 and 76% of the patients, respectively. Altogether, 269 patients (8.6%) had an incident CVD event and 370 patients (10.8%) progressed to a higher level of albuminuria or to end-stage renal disease. RESULTS: PP was higher at baseline in patients who experienced a CVD event (66 ± 18 vs. 52 ± 14 mmHg; P < 0.001) or progressed in their renal status (58 ± 18 vs. 54 ± 15 mmHg; P < 0.01) during follow-up. In a Cox regression model, PP was independently associated with a first ever CVD event (hazard ratio per 10 mmHg 1.22 [95% CI 1.10–1.34]) but not progression of renal disease (1.00 [0.89–1.12]) after adjustments for traditional risk factors. CONCLUSIONS: PP, a marker of arterial stiffness, is a risk factor for cardiovascular complications but not for diabetic nephropathy in patients with T1D. American Diabetes Association 2011-04 2011-03-21 /pmc/articles/PMC3064046/ /pubmed/21330642 http://dx.doi.org/10.2337/dc10-2013 Text en © 2011 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
spellingShingle Original Research
Gordin, Daniel
Wadén, Johan
Forsblom, Carol
Thorn, Lena
Rosengård-Bärlund, Milla
Tolonen, Nina
Saraheimo, Markku
Harjutsalo, Valma
Groop, Per-Henrik
Pulse Pressure Predicts Incident Cardiovascular Disease but Not Diabetic Nephropathy in Patients With Type 1 Diabetes (The FinnDiane Study)
title Pulse Pressure Predicts Incident Cardiovascular Disease but Not Diabetic Nephropathy in Patients With Type 1 Diabetes (The FinnDiane Study)
title_full Pulse Pressure Predicts Incident Cardiovascular Disease but Not Diabetic Nephropathy in Patients With Type 1 Diabetes (The FinnDiane Study)
title_fullStr Pulse Pressure Predicts Incident Cardiovascular Disease but Not Diabetic Nephropathy in Patients With Type 1 Diabetes (The FinnDiane Study)
title_full_unstemmed Pulse Pressure Predicts Incident Cardiovascular Disease but Not Diabetic Nephropathy in Patients With Type 1 Diabetes (The FinnDiane Study)
title_short Pulse Pressure Predicts Incident Cardiovascular Disease but Not Diabetic Nephropathy in Patients With Type 1 Diabetes (The FinnDiane Study)
title_sort pulse pressure predicts incident cardiovascular disease but not diabetic nephropathy in patients with type 1 diabetes (the finndiane study)
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064046/
https://www.ncbi.nlm.nih.gov/pubmed/21330642
http://dx.doi.org/10.2337/dc10-2013
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