Cyclin-Dependent Kinase 5 Promotes Pancreatic β-Cell Survival via Fak-Akt Signaling Pathways

OBJECTIVE: Cyclin-dependent kinase 5 (CDK5) regulatory subunit-associated protein 1-like 1 has recently been linked to type 2 diabetes by genome-wide association studies. While CDK5 and its regulatory protein p35 are both expressed and display enzymatic activity in pancreatic β-cells, their precise...

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Detalles Bibliográficos
Autores principales: Daval, Marie, Gurlo, Tatyana, Costes, Safia, Huang, Chang-jiang, Butler, Peter C.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2011
Materias:
Islet Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064092/
https://www.ncbi.nlm.nih.gov/pubmed/21378178
http://dx.doi.org/10.2337/db10-1048

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064092/
https://www.ncbi.nlm.nih.gov/pubmed/21378178
http://dx.doi.org/10.2337/db10-1048

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