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Cyclin-Dependent Kinase 5 Promotes Pancreatic β-Cell Survival via Fak-Akt Signaling Pathways

OBJECTIVE: Cyclin-dependent kinase 5 (CDK5) regulatory subunit-associated protein 1-like 1 has recently been linked to type 2 diabetes by genome-wide association studies. While CDK5 and its regulatory protein p35 are both expressed and display enzymatic activity in pancreatic β-cells, their precise...

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Detalles Bibliográficos
Autores principales:	Daval, Marie, Gurlo, Tatyana, Costes, Safia, Huang, Chang-jiang, Butler, Peter C.
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2011
Materias:	Islet Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064092/ https://www.ncbi.nlm.nih.gov/pubmed/21378178 http://dx.doi.org/10.2337/db10-1048

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