Cargando…

Δ40 Isoform of p53 Controls β-Cell Proliferation and Glucose Homeostasis in Mice

OBJECTIVE: Investigating the dynamics of pancreatic β-cell mass is critical for developing strategies to treat both type 1 and type 2 diabetes. p53, a key regulator of the cell cycle and apoptosis, has mostly been a focus of investigation as a tumor suppressor. Although p53 alternative transcripts c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hinault, Charlotte, Kawamori, Dan, Liew, Chong Wee, Maier, Bernhard, Hu, Jiang, Keller, Susanna R., Mirmira, Raghavendra G., Scrable, Heidi, Kulkarni, Rohit N.
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2011
Materias:	Islet Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064094/ https://www.ncbi.nlm.nih.gov/pubmed/21357466 http://dx.doi.org/10.2337/db09-1379

Ejemplares similares

Palmitate Induces mRNA Translation and Increases ER Protein Load in Islet β-Cells via Activation of the Mammalian Target of Rapamycin Pathway
por: Hatanaka, Masayuki, et al.
Publicado: (2014)

Methyltransferase Set7/9 Maintains Transcription and Euchromatin Structure at Islet-Enriched Genes
por: Deering, Tye G., et al.
Publicado: (2009)

Dominant effects of Δ40p53 on p53 function and melanoma cell fate
por: Takahashi, Rie, et al.
Publicado: (2013)

Islet β-Cell Endoplasmic Reticulum Stress Precedes the Onset of Type 1 Diabetes in the Nonobese Diabetic Mouse Model
por: Tersey, Sarah A., et al.
Publicado: (2012)

The Hypoglycemic Phenotype Is Islet Cell–Autonomous in Short-Chain Hydroxyacyl-CoA Dehydrogenase–Deficient Mice
por: Molven, Anders, et al.
Publicado: (2016)

Interleukin-6 Reduces β-Cell Oxidative Stress by Linking Autophagy With the Antioxidant Response
por: Marasco, Michelle R., et al.
Publicado: (2018)

Soluble Factors Secreted by T Cells Promote β-Cell Proliferation
por: Dirice, Ercument, et al.
Publicado: (2014)

Elevations in Circulating Methylated and Unmethylated Preproinsulin DNA in New-Onset Type 1 Diabetes
por: Fisher, Marisa M., et al.
Publicado: (2015)

Role of Lipid Peroxidation and PPAR-δ in Amplifying Glucose-Stimulated Insulin Secretion
por: Cohen, Guy, et al.
Publicado: (2011)

Induction of the ChREBPβ Isoform Is Essential for Glucose-Stimulated β-Cell Proliferation
por: Zhang, Pili, et al.
Publicado: (2015)

Somatostatin Secreted by Islet δ-Cells Fulfills Multiple Roles as a Paracrine Regulator of Islet Function
por: Hauge-Evans, Astrid C., et al.
Publicado: (2009)

Regulation of Calcium-Permeable TRPV2 Channel by Insulin in Pancreatic β-Cells
por: Hisanaga, Etsuko, et al.
Publicado: (2009)

Gene Silencing of Phogrin Unveils Its Essential Role in Glucose-Responsive Pancreatic β-Cell Growth
por: Torii, Seiji, et al.
Publicado: (2009)

Islet α-, β-, and δ-Cell Development Is Controlled by the Ldb1 Coregulator, Acting Primarily With the Islet-1 Transcription Factor
por: Hunter, Chad S., et al.
Publicado: (2013)

Pericyte Control of Blood Flow in Intraocular Islet Grafts Impacts Glucose Homeostasis in Mice
por: Tamayo, Alejandro, et al.
Publicado: (2022)

Specific Control of Pancreatic Endocrine β- and δ-Cell Mass by Class IIa Histone Deacetylases HDAC4, HDAC5, and HDAC9
por: Lenoir, Olivia, et al.
Publicado: (2011)

The ΔF508 Mutation in the Cystic Fibrosis Transmembrane Conductance Regulator Is Associated With Progressive Insulin Resistance and Decreased Functional β-Cell Mass in Mice
por: Fontés, Ghislaine, et al.
Publicado: (2015)

Antioxidants Complement the Requirement for Protein Chaperone Function to Maintain β-Cell Function and Glucose Homeostasis
por: Han, Jaeseok, et al.
Publicado: (2015)

YY1 Regulates Glucose Homeostasis Through Controlling Insulin Transcription in Pancreatic β-Cells
por: Liu, Di, et al.
Publicado: (2022)

Insulin Resistance Alters Islet Morphology in Nondiabetic Humans
por: Mezza, Teresa, et al.
Publicado: (2014)

The Fatty Acid Receptor GPR40 Plays a Role in Insulin Secretion In Vivo After High-Fat Feeding
por: Kebede, Melkam, et al.
Publicado: (2008)

Wld(S) Enhances Insulin Transcription and Secretion via a SIRT1-Dependent Pathway and Improves Glucose Homeostasis
por: Wu, Jingxia, et al.
Publicado: (2011)

Overexpression of Kinase-Dead mTOR Impairs Glucose Homeostasis by Regulating Insulin Secretion and Not β-Cell Mass
por: Alejandro, Emilyn U., et al.
Publicado: (2017)

Mafa Enables Pdx1 to Effectively Convert Pancreatic Islet Progenitors and Committed Islet α-Cells Into β-Cells In Vivo
por: Matsuoka, Taka-aki, et al.
Publicado: (2017)

Loss of Both ABCA1 and ABCG1 Results in Increased Disturbances in Islet Sterol Homeostasis, Inflammation, and Impaired β-Cell Function
por: Kruit, Janine K., et al.
Publicado: (2012)

Pak3 Promotes Cell Cycle Exit and Differentiation of β-Cells in the Embryonic Pancreas and Is Necessary to Maintain Glucose Homeostasis in Adult Mice
por: Piccand, Julie, et al.
Publicado: (2014)

Type 2 Diabetes–Associated K(+) Channel TALK-1 Modulates β-Cell Electrical Excitability, Second-Phase Insulin Secretion, and Glucose Homeostasis
por: Vierra, Nicholas C., et al.
Publicado: (2015)

Inhibition of DYRK1A Stimulates Human β-Cell Proliferation
por: Dirice, Ercument, et al.
Publicado: (2016)

Cannabinoids Inhibit Insulin Receptor Signaling in Pancreatic β-Cells
por: Kim, Wook, et al.
Publicado: (2011)

p53 isoform Δ113p53 promotes zebrafish heart regeneration by maintaining redox homeostasis
por: Ye, Shengfan, et al.
Publicado: (2020)

P44, the ‘longevity-assurance’ isoform of P53, regulates tau phosphorylation and is activated in an age-dependent fashion
por: Pehar, Mariana, et al.
Publicado: (2014)

The Peri-islet Basement Membrane, a Barrier to Infiltrating Leukocytes in Type 1 Diabetes in Mouse and Human
por: Korpos, Éva, et al.
Publicado: (2013)

Effect of p53 and its N‐terminally truncated isoform, Δ40p53, on breast cancer migration and invasion
por: Zhang, Xiajie, et al.
Publicado: (2021)

Effects of Δ40p53, an isoform of p53 lacking the N-terminus, on transactivation capacity of the tumor suppressor protein p53
por: Hafsi, Hind, et al.
Publicado: (2013)

Effects of PNPLA3 on Liver Fat and Metabolic Profile in Hispanic Children and Adolescents
por: Goran, Michael I., et al.
Publicado: (2010)

The Δ133p53 Isoforms, Tuners of the p53 Pathway
por: Joruiz, Sebastien M., et al.
Publicado: (2020)

Loss of the p53 transactivation domain results in high amyloid aggregation of the Δ40p53 isoform in endometrial carcinoma cells
por: Melo dos Santos, Nataly, et al.
Publicado: (2019)

Downregulation of Carnitine Acyl-Carnitine Translocase by miRNAs 132 and 212 Amplifies Glucose-Stimulated Insulin Secretion
por: Soni, Mufaddal S., et al.
Publicado: (2014)

Adaptive homeostasis and the p53 isoform network
por: Mehta, Sunali, et al.
Publicado: (2021)

National Institutes of Health–Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities
por: Ricordi, Camillo, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_helner66k06tbkm8ia47rf6fak