Cargando…

Prevention of “Humanized” Diabetogenic CD8 T-Cell Responses in HLA-Transgenic NOD Mice by a Multipeptide Coupled-Cell Approach

OBJECTIVE: Type 1 diabetes can be inhibited in standard NOD mice by autoantigen-specific immunotherapy targeting pathogenic CD8+ T-cells. NOD.β2m(null).HHD mice expressing human HLA-A2.1 but lacking murine major histocompatibility complex class I molecules develop diabetes characterized by CD8 T-cel...

Descripción completa

Detalles Bibliográficos
Autores principales:	Niens, Marijke, Grier, Alexandra E., Marron, Michele, Kay, Thomas W.H., Greiner, Dale L., Serreze, David V.
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2011
Materias:	Immunology and Transplantation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064096/ https://www.ncbi.nlm.nih.gov/pubmed/21346176 http://dx.doi.org/10.2337/db10-1523

Ejemplares similares

Idd9/11 Genetic Locus Regulates Diabetogenic Activity of CD4 T-Cells in Nonobese Diabetic (NOD) Mice
por: Chen, Yi-Guang, et al.
Publicado: (2008)

In Vivo Enrichment of Diabetogenic T Cells
por: Thelin, Martin A., et al.
Publicado: (2017)

Idd Loci Synergize to Prolong Islet Allograft Survival Induced by Costimulation Blockade in NOD Mice
por: Mangada, Julie, et al.
Publicado: (2009)

Loss of Intra-Islet CD20 Expression May Complicate Efficacy of B-Cell–Directed Type 1 Diabetes Therapies
por: Serreze, David V., et al.
Publicado: (2011)

Diabetogenic T-Cell Clones Recognize an Altered Peptide of Chromogranin A
por: Delong, Thomas, et al.
Publicado: (2012)

Complete Diabetes Protection Despite Delayed Thymic Tolerance in NOD8.3 TCR Transgenic Mice Due to Antigen-Induced Extrathymic Deletion of T Cells
por: Krishnamurthy, Balasubramanian, et al.
Publicado: (2012)

Islet Amyloid Polypeptide Is a Target Antigen for Diabetogenic CD4(+) T Cells
por: Delong, Thomas, et al.
Publicado: (2011)

Modulation of Redox Balance Leaves Murine Diabetogenic TH1 T Cells “LAG-3-ing” Behind
por: Delmastro, Meghan M., et al.
Publicado: (2012)

HLA-A2–Matched Peripheral Blood Mononuclear Cells From Type 1 Diabetic Patients, but Not Nondiabetic Donors, Transfer Insulitis to NOD-scid/γc(null)/HLA-A2 Transgenic Mice Concurrent With the Expansion of Islet-Specific CD8(+) T cells
por: Whitfield-Larry, Fatima, et al.
Publicado: (2011)

Loss of NOX-Derived Superoxide Exacerbates Diabetogenic CD4 T-Cell Effector Responses in Type 1 Diabetes
por: Padgett, Lindsey E., et al.
Publicado: (2015)

Slc11a1 Enhances the Autoimmune Diabetogenic T-Cell Response by Altering Processing and Presentation of Pancreatic Islet Antigens
por: Dai, Yang D., et al.
Publicado: (2009)

B-Lymphocytes Expressing an Ig Specificity Recognizing the Pancreatic β-Cell Autoantigen Peripherin Are Potent Contributors to Type 1 Diabetes Development in NOD Mice
por: Leeth, Caroline M., et al.
Publicado: (2016)

T-replete HLA-matched grafts vs T-depleted HLA-mismatched grafts in inborn errors of immunity
por: Lum, Su Han, et al.
Publicado: (2022)

IL-13Rα1 Expression on β-Cell–Specific T Cells in NOD Mice
por: Rasche, Sarah S., et al.
Publicado: (2011)

Microbial antigen mimics activate diabetogenic CD8 T cells in NOD mice
por: Tai, Ningwen, et al.
Publicado: (2016)

Unexpected Acceleration of Type 1 Diabetes by Transgenic Expression of B7-H1 in NOD Mouse Peri-Islet Glia
por: Yantha, Jason, et al.
Publicado: (2010)

Assessment of HLA-B genetic variation with an HLA-B leader tool and implications in clinical transplantation
por: Sajulga, Ray, et al.
Publicado: (2022)

Assessment of HLA-DPB1 genetic variation using an HLA-DP tool and its implications in clinical transplantation
por: Sajulga, Ray, et al.
Publicado: (2023)

Recognition of Human Proinsulin Leader Sequence by Class I–Restricted T-Cells in HLA-A*0201 Transgenic Mice and in Human Type 1 Diabetes
por: Toma, Andréa, et al.
Publicado: (2009)

Impact of GVHD prophylaxis on CMV reactivation and disease after HLA-matched peripheral blood stem cell transplantation
por: Ueda Oshima, Masumi, et al.
Publicado: (2023)

Ganglioside GM1 Deficiency in Effector T Cells From NOD Mice Induces Resistance to Regulatory T-Cell Suppression
por: Wu, Gusheng, et al.
Publicado: (2011)

Prevention of Autoimmune Diabetes and Induction of β-Cell Proliferation in NOD Mice by Hyperbaric Oxygen Therapy
por: Faleo, Gaetano, et al.
Publicado: (2012)

Human Immune System Development and Rejection of Human Islet Allografts in Spontaneously Diabetic NOD-Rag1(null) IL2rγ(null) Ins2(Akita) Mice
por: Brehm, Michael A., et al.
Publicado: (2010)

Plasmacytoid Precursor Dendritic Cells From NOD Mice Exhibit Impaired Function : Are They a Component of Diabetes Pathogenesis?
por: Huang, Yiming, et al.
Publicado: (2008)

ZnT8-Reactive T Cells Are Weakly Pathogenic in NOD Mice but Can Participate in Diabetes Under Inflammatory Conditions
por: Nayak, Deepak K., et al.
Publicado: (2014)

Treg-Specific CD226 Deletion Reduces Diabetes Incidence in NOD Mice by Improving Regulatory T-Cell Stability
por: Thirawatananond, Puchong, et al.
Publicado: (2023)

Peptidylarginine Deiminase Inhibition Prevents Diabetes Development in NOD Mice
por: Sodré, Fernanda M.C., et al.
Publicado: (2021)

A Novel Clinically Relevant Strategy to Abrogate Autoimmunity and Regulate Alloimmunity in NOD Mice
por: Vergani, Andrea, et al.
Publicado: (2010)

HLA-matching with PTCy: a reanalysis of a CIBMTR dataset with propensity score matching and donor age
por: Ambinder, Alexander, et al.
Publicado: (2022)

Impact of allele-level HLA matching on outcomes after double cord blood transplantation in adults with malignancies
por: Fatobene, Giancarlo, et al.
Publicado: (2023)

Germline TRAV5D-4 T-Cell Receptor Sequence Targets a Primary Insulin Peptide of NOD Mice
por: Nakayama, Maki, et al.
Publicado: (2012)

Thymic Stromal Lymphopoietin and Thymic Stromal Lymphopoietin–Conditioned Dendritic Cells Induce Regulatory T-Cell Differentiation and Protection of NOD Mice Against Diabetes
por: Besin, Gilles, et al.
Publicado: (2008)

Improved GRFS after posttransplant cyclophosphamide-based vs ATG-based HLA-mismatched unrelated donor transplant
por: Jimenez Jimenez, Antonio, et al.
Publicado: (2022)

Islet-Specific CTL Cloned from a Type 1 Diabetes Patient Cause Beta-Cell Destruction after Engraftment into HLA-A2 Transgenic NOD/SCID/IL2RG Null Mice
por: Unger, Wendy W. J., et al.
Publicado: (2012)

Immunoglobulin-Like Transcript 3-Fc Suppresses T-Cell Responses to Allogeneic Human Islet Transplants in hu-NOD/SCID Mice
por: Vlad, George, et al.
Publicado: (2008)

Following the Fate of One Insulin-Reactive CD4 T cell: Conversion Into Teffs and Tregs in the Periphery Controls Diabetes in NOD Mice
por: Fousteri, Georgia, et al.
Publicado: (2012)

Characterization of a Multipeptide Lantibiotic Locus in Streptococcus pneumoniae
por: Maricic, Natalie, et al.
Publicado: (2016)

IRAK-M Deficiency Promotes the Development of Type 1 Diabetes in NOD Mice
por: Tan, Qiyuan, et al.
Publicado: (2014)

Combination Therapy Reverses Hyperglycemia in NOD Mice With Established Type 1 Diabetes
por: Xue, Song, et al.
Publicado: (2015)

Dipeptidyl Peptidase IV Inhibition With MK0431 Improves Islet Graft Survival in Diabetic NOD Mice Partially via T-Cell Modulation
por: Kim, Su-Jin, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_aa7dd4sdkcl4ee7hs04vg41r7i