Structural basis for substrate discrimination and integrin binding by autotaxin

Autotaxin (ATX) or ecto-nucleotide pyrophosphatase/phosphodiesterase-2 (ENPP2) is a secreted lysophospholipase D that generates the lipid mediator lysophosphatidic acid (LPA), a mitogen and chemo-attractant for many cell types. ATX-LPA signaling has roles in various pathologies including tumour prog...

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Detalles Bibliográficos
Autores principales: Hausmann, Jens, Kamtekar, Satwik, Christodoulou, Evangelos, Day, Jacqueline E., Wu, Tao, Fulkerson, Zachary, Albers, Harald M.H.G., van Meeteren, Laurens A., Houben, Anna, van Zeijl, Leonie, Jansen, Silvia, Andries, Maria, Hall, Troii, Pegg, Lyle E., Benson, Timothy E., Kasiem, Mobien, Harlos, Karl, Vander Kooi, Craig, Smyth, Susan S., Ovaa, Huib, Bollen, Mathieu, Morris, Andrew J., Moolenaar, Wouter H., Perrakis, Anastassis
Formato: Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064516/
https://www.ncbi.nlm.nih.gov/pubmed/21240271
http://dx.doi.org/10.1038/nsmb.1980

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