The Induction of MicroRNA Targeting IRS-1 Is Involved in the Development of Insulin Resistance under Conditions of Mitochondrial Dysfunction in Hepatocytes

BACKGROUND: Mitochondrial dysfunction induces insulin resistance in myocytes via a reduction of insulin receptor substrate-1 (IRS-1) expression. However, the effect of mitochondrial dysfunction on insulin sensitivity is not understood well in hepatocytes. Although research has implicated the transla...

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Detalles Bibliográficos
Autores principales: Ryu, Hyun Su, Park, Seung-Yoon, Ma, Duan, Zhang, Jin, Lee, Wan
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064581/
https://www.ncbi.nlm.nih.gov/pubmed/21464990
http://dx.doi.org/10.1371/journal.pone.0017343

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