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Stoichiometry and affinity for thymine DNA glycosylase binding to specific and nonspecific DNA

Deamination of 5-methylcytosine to thymine creates mutagenic G·T mispairs, contributing to cancer and genetic disease. Thymine DNA glycosylase (TDG) removes thymine from these G·T lesions, and follow-on base excision repair yields a G·C pair. A previous crystal structure revealed TDG (catalytic doma...

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Detalles Bibliográficos
Autores principales:	Morgan, Michael T., Maiti, Atanu, Fitzgerald, Megan E., Drohat, Alexander C.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2011
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064789/ https://www.ncbi.nlm.nih.gov/pubmed/21097883 http://dx.doi.org/10.1093/nar/gkq1164

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