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CtIP and MRN promote non-homologous end-joining of etoposide-induced DNA double-strand breaks in G1

Topoisomerases class II (topoII) cleave and re-ligate the DNA double helix to allow the passage of an intact DNA strand through it. Chemotherapeutic drugs such as etoposide target topoII, interfere with the normal enzymatic cleavage/re-ligation reaction and create a DNA double-strand break (DSB) wit...

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Detalles Bibliográficos
Autores principales:	Quennet, Verena, Beucher, Andrea, Barton, Olivia, Takeda, Shunichi, Löbrich, Markus
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2011
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064790/ https://www.ncbi.nlm.nih.gov/pubmed/21087997 http://dx.doi.org/10.1093/nar/gkq1175

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