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Poly(ADP-ribose)glycohydrolase is an upstream regulator of Ca(2+) fluxes in oxidative cell death

Oxidative DNA damage to cells activates poly(ADP-ribose)polymerase-1 (PARP-1) and the poly(ADP-ribose) formed is rapidly degraded to ADP-ribose by poly(ADP-ribose)glycohydrolase (PARG). Here we show that PARP-1 and PARG control extracellular Ca(2+) fluxes through melastatin-like transient receptor p...

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Detalles Bibliográficos
Autores principales:	Blenn, C., Wyrsch, P., Bader, J., Bollhalder, M., Althaus, Felix R.
Formato:	Texto
Lenguaje:	English
Publicado:	SP Birkhäuser Verlag Basel 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064896/ https://www.ncbi.nlm.nih.gov/pubmed/20878536 http://dx.doi.org/10.1007/s00018-010-0533-1

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