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MicroRNA as a Novel Modulator in Head and Neck Squamous Carcinoma

MicroRNAs have emerged as important regulators of cell proliferation, development, cancer formation, stress responses, cell death, and other physiological conditions in the past decade. On the other hand, head and neck cancer is one of the top ten most common cancers worldwide. Recent advances in mi...

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Detalles Bibliográficos
Autores principales: Chen, Li-Hsin, Tsai, Kun-Ling, Chen, Yi-Wei, Yu, Cheng-Chia, Chang, Kuo-Wei, Chiou, Shi-Hwa, Ku, Hung-Hai, Chu, Pen-Yuan, Tseng, Ling-Ming, Huang, Pin-I, Lo, Wen-Liang
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065009/
https://www.ncbi.nlm.nih.gov/pubmed/21461395
http://dx.doi.org/10.1155/2010/135632
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author Chen, Li-Hsin
Tsai, Kun-Ling
Chen, Yi-Wei
Yu, Cheng-Chia
Chang, Kuo-Wei
Chiou, Shi-Hwa
Ku, Hung-Hai
Chu, Pen-Yuan
Tseng, Ling-Ming
Huang, Pin-I
Lo, Wen-Liang
author_facet Chen, Li-Hsin
Tsai, Kun-Ling
Chen, Yi-Wei
Yu, Cheng-Chia
Chang, Kuo-Wei
Chiou, Shi-Hwa
Ku, Hung-Hai
Chu, Pen-Yuan
Tseng, Ling-Ming
Huang, Pin-I
Lo, Wen-Liang
author_sort Chen, Li-Hsin
collection PubMed
description MicroRNAs have emerged as important regulators of cell proliferation, development, cancer formation, stress responses, cell death, and other physiological conditions in the past decade. On the other hand, head and neck cancer is one of the top ten most common cancers worldwide. Recent advances in microRNAs have revealed their prominent role in regulating gene expression and provided new aspects of applications in diagnosis, prognosis, and therapeutic strategies in head and neck squamous carcinoma. In the present paper, we focus on microRNAs showing significant differences between normal and tumor cells or between cells with differential ability of metastasis. We also emphasize specific microRNAs that could modulate tumor cell properties, such as apoptosis, metastasis, and proliferation. These microRNAs possess the potential to be applied on clinical therapy in the future.
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spelling pubmed-30650092011-03-31 MicroRNA as a Novel Modulator in Head and Neck Squamous Carcinoma Chen, Li-Hsin Tsai, Kun-Ling Chen, Yi-Wei Yu, Cheng-Chia Chang, Kuo-Wei Chiou, Shi-Hwa Ku, Hung-Hai Chu, Pen-Yuan Tseng, Ling-Ming Huang, Pin-I Lo, Wen-Liang J Oncol Review Article MicroRNAs have emerged as important regulators of cell proliferation, development, cancer formation, stress responses, cell death, and other physiological conditions in the past decade. On the other hand, head and neck cancer is one of the top ten most common cancers worldwide. Recent advances in microRNAs have revealed their prominent role in regulating gene expression and provided new aspects of applications in diagnosis, prognosis, and therapeutic strategies in head and neck squamous carcinoma. In the present paper, we focus on microRNAs showing significant differences between normal and tumor cells or between cells with differential ability of metastasis. We also emphasize specific microRNAs that could modulate tumor cell properties, such as apoptosis, metastasis, and proliferation. These microRNAs possess the potential to be applied on clinical therapy in the future. Hindawi Publishing Corporation 2010 2011-02-15 /pmc/articles/PMC3065009/ /pubmed/21461395 http://dx.doi.org/10.1155/2010/135632 Text en Copyright © 2010 Li-Hsin Chen et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Chen, Li-Hsin
Tsai, Kun-Ling
Chen, Yi-Wei
Yu, Cheng-Chia
Chang, Kuo-Wei
Chiou, Shi-Hwa
Ku, Hung-Hai
Chu, Pen-Yuan
Tseng, Ling-Ming
Huang, Pin-I
Lo, Wen-Liang
MicroRNA as a Novel Modulator in Head and Neck Squamous Carcinoma
title MicroRNA as a Novel Modulator in Head and Neck Squamous Carcinoma
title_full MicroRNA as a Novel Modulator in Head and Neck Squamous Carcinoma
title_fullStr MicroRNA as a Novel Modulator in Head and Neck Squamous Carcinoma
title_full_unstemmed MicroRNA as a Novel Modulator in Head and Neck Squamous Carcinoma
title_short MicroRNA as a Novel Modulator in Head and Neck Squamous Carcinoma
title_sort microrna as a novel modulator in head and neck squamous carcinoma
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065009/
https://www.ncbi.nlm.nih.gov/pubmed/21461395
http://dx.doi.org/10.1155/2010/135632
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