Cargando…

High T-cell immune activation and immune exhaustion among individuals with suboptimal CD4 recovery after 4 years of antiretroviral therapy in an African cohort

BACKGROUND: Antiretroviral therapy (ART) partially corrects immune dysfunction associated with HIV infection. The levels of T-cell immune activation and exhaustion after long-term, suppressive ART and their correlation with CD4 T-cell count reconstitution among ART-treated patients in African cohort...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nakanjako, Damalie, Ssewanyana, Isaac, Mayanja-Kizza, Harriet, Kiragga, Agnes, Colebunders , Robert, Manabe, Yukari C, Nabatanzi , Rose, Kamya, Moses R, Cao, Huyen
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065409/ https://www.ncbi.nlm.nih.gov/pubmed/21299909 http://dx.doi.org/10.1186/1471-2334-11-43

Ejemplares similares

Impaired T-cell proliferation among HAART-treated adults with suboptimal CD4 recovery in an African cohort
por: Nakanjako, Damalie, et al.
Publicado: (2013)

Atorvastatin reduces T-cell activation and exhaustion among HIV-infected cART-treated suboptimal immune responders in Uganda: a randomised crossover placebo-controlled trial
por: Nakanjako, Damalie, et al.
Publicado: (2015)

High CD56(++)CD16(-) natural killer (NK) cells among suboptimal immune responders after four years of suppressive antiretroviral therapy in an African adult HIV treatment cohort
por: Bayigga, Lois, et al.
Publicado: (2014)

Baseline severe anaemia should not preclude use of zidovudine in antiretroviral-eligible patients in resource-limited settings
por: Kiragga, Agnes N, et al.
Publicado: (2010)

Sub-optimal CD4 reconstitution despite viral suppression in an urban cohort on Antiretroviral Therapy (ART) in sub-Saharan Africa: Frequency and clinical significance
por: Nakanjako, Damalie, et al.
Publicado: (2008)

Chest X-ray interpretation does not complement Xpert MTB/RIF in diagnosis of smear-negative pulmonary tuberculosis among TB-HIV co-infected adults in a resource-limited setting
por: Nakiyingi, Lydia, et al.
Publicado: (2021)

Doctoral training in Uganda: evaluation of mentoring best practices at Makerere university college of health sciences
por: Nakanjako, Damalie, et al.
Publicado: (2014)

Experiences of patients who developed oral mucositis during solid neoplasms treatment: a Ugandan qualitative study
por: Kamulegeya, Adriane, et al.
Publicado: (2021)

Extensive dental caries in a HIV positive adult patient on ART; case report and literature review
por: Kalanzi, Dunstan, et al.
Publicado: (2018)

Prevalence of HIV-Associated Metabolic Abnormalities among Patients Taking First-Line Antiretroviral Therapy in Uganda
por: Omech, Bernard, et al.
Publicado: (2012)

Incident Tuberculosis during Antiretroviral Therapy Contributes to Suboptimal Immune Reconstitution in a Large Urban HIV Clinic in Sub-Saharan Africa
por: Hermans, Sabine M., et al.
Publicado: (2010)

Antiretroviral Treatment-Associated Tuberculosis in a Prospective Cohort of HIV-Infected Patients Starting ART
por: Worodria, William, et al.
Publicado: (2011)

Increased Levels of Caspase-1 and IL-1β Among Adults With Persistent Immune Activation After 12 Years of Suppressive Antiretroviral Therapy in the Infectious Diseases Institute HIV Treatment Cohort
por: Nabatanzi, Rose, et al.
Publicado: (2023)

Mentorship needs at academic institutions in resource-limited settings: a survey at makerere university college of health sciences
por: Nakanjako, Damalie, et al.
Publicado: (2011)

Longitudinal patients' cohorts for impactful research and HIV care at the Infectious Diseases Institute
por: Castelnuovo, Barbara, et al.
Publicado: (2022)

Evaluation of WHO Criteria for Viral Failure in Patients on Antiretroviral Treatment in Resource-Limited Settings
por: Castelnuovo, Barbara, et al.
Publicado: (2011)

Monocyte Dysfunction, Activation, and Inflammation After Long-Term Antiretroviral Therapy in an African Cohort
por: Nabatanzi, Rose, et al.
Publicado: (2019)

Low prevalence of Plasmodium falciparum antigenaemia among asymptomatic HAART-treated adults in an urban cohort in Uganda
por: Nakanjako, Damalie, et al.
Publicado: (2011)

Innate lymphoid cell dysfunction during long-term suppressive antiretroviral therapy in an African cohort
por: Nabatanzi, Rose, et al.
Publicado: (2021)

Prevalence and factors associated with dental caries in patients attending an HIV care clinic in Uganda: a cross sectional study
por: Kalanzi, Dunstan, et al.
Publicado: (2019)

Delayed Antiretroviral Therapy (ART) Initiation among Hospitalized Adults in a Resource-Limited Settings: A Challenge to the Global Target of ART for 90% of HIV-Infected Individuals
por: Ingabire, Prossie Merab, et al.
Publicado: (2019)

Predictors and outcomes of mycobacteremia among HIV-infected smear- negative presumptive tuberculosis patients in Uganda
por: Nakiyingi, Lydia, et al.
Publicado: (2015)

Sub-Optimal Vitamin B-12 Levels among ART-Naïve HIV-Positive Individuals in an Urban Cohort in Uganda
por: Semeere, Aggrey S., et al.
Publicado: (2012)

A need to accelerate health research productivity in an African University: the case of Makerere University College of Health Sciences
por: Nakanjako, Damalie, et al.
Publicado: (2017)

Dental Caries Pattern and Treatment Needs among Ugandan Adolescent Students: A Cross-Sectional Study
por: Ndagire, Barbara, et al.
Publicado: (2020)

Predictors for MTB Culture-Positivity among HIV-Infected Smear-Negative Presumptive Tuberculosis Patients in Uganda: Application of New Tuberculosis Diagnostic Technology
por: Nakiyingi, Lydia, et al.
Publicado: (2015)

Among Patients with Sustained Viral Suppression in a Resource-Limited Setting, CD4 Gains Are Continuous Although Gender-Based Differences Occur
por: Sempa, Joseph B., et al.
Publicado: (2013)

Erratum to: B cell sub-types following acute malaria and associations with clinical immunity
por: Sullivan, Richard T., et al.
Publicado: (2016)

Effects of HIV infection and ART on phenotype and function of circulating monocytes, natural killer, and innate lymphoid cells
por: Nabatanzi, Rose, et al.
Publicado: (2018)

B cell sub-types following acute malaria and associations with clinical immunity
por: Sullivan, Richard T., et al.
Publicado: (2016)

Infectious Diseases Institute at Makerere University College of Health Sciences: a case study of a sustainable capacity building model for health care, research and training
por: Nakanjako, Damalie, et al.
Publicado: (2022)

An Autopsy Study Describing Causes of Death and Comparing Clinico-Pathological Findings among Hospitalized Patients in Kampala, Uganda
por: Cox, Janneke A., et al.
Publicado: (2012)

Monocyte Phenotype and IFN-γ-Inducible Cytokine Responses Are Associated with Cryptococcal Immune Reconstitution Inflammatory Syndrome
por: Meya, David B., et al.
Publicado: (2017)

LPS-Binding Protein and IL-6 Mark Paradoxical Tuberculosis Immune Reconstitution Inflammatory Syndrome in HIV Patients
por: Goovaerts, Odin, et al.
Publicado: (2013)

Aberrant natural killer (NK) cell activation and dysfunction among ART-treated HIV-infected adults in an African cohort
por: Nabatanzi, Rose, et al.
Publicado: (2019)

Avidity of anti-malarial antibodies inversely related to transmission intensity at three sites in Uganda
por: Ssewanyana, Isaac, et al.
Publicado: (2017)

Lower Pre-Treatment T Cell Activation in Early- and Late-Onset Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome
por: Goovaerts, Odin, et al.
Publicado: (2015)

A decade of antiretroviral therapy in Uganda: what are the emerging causes of death?
por: Kiragga, Agnes N., et al.
Publicado: (2019)

Burden of tuberculosis disease among adolescents in a rural cohort in Eastern Uganda
por: Waako, James, et al.
Publicado: (2013)

Determinants of hypertension in a young adult Ugandan population in epidemiological transition—the MEPI-CVD survey
por: Kayima, James, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_23csvvo90olhjgpo6ipos0imhk